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Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population

Abstract : Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies. This study characterized the anti-spike IgG titers in 13,971 participants included in a French multicohort population-based serological survey on COVID-19 between April and October 2020 and followed-up with serological testing between May and October 2021. Eight follow-up profiles were defined depending on SARS-CoV-2 infection (0, 1 or 2) and COVID-19 vaccination (0, 1, 2 or 3). The anti-spike titer was lower in adults with no vaccination even in case of infection or reinfection, while it was higher in adults with infection followed by vaccination. The anti-spike titer was negatively correlated with age in vaccinated but uninfected adults, whereas it was positively correlated with age in unvaccinated but infected adults. In adults with 2 vaccine injections and no infection, the vaccine protocol, age, gender, and time since the last vaccine injection were independently associated with the anti-spike titer. The decrease in anti-spike titer was much more rapid in vaccinated than in infected subjects. These results highlight the strong heterogeneity of the antibody response against SARS-CoV-2 in the general population depending on previous infection and vaccination.
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Submitted on : Tuesday, August 30, 2022 - 2:25:15 PM
Last modification on : Friday, October 28, 2022 - 4:24:05 PM


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Fabrice Carrat, Paola Mariela Saba Villarroel, Nathanaël Lapidus, Toscane Fourié, Hélène Blanché, et al.. Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population. Scientific Reports, 2022, 12 (1), pp.8622. ⟨10.1038/s41598-022-11787-4⟩. ⟨hal-03737986⟩



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