Incremental value of 18F-fluorocholine PET/CT in the localization of double parathyroid adenomas

Paul Lalire 1 Sang Ly 2 Sophie Deguelte 3 Martine Patey 4 David Morland 5, 6, 7
1 Unité thyroïde, Institut Jean Godinot, Reims
2 Service d'Endocrinologie-Diabétologie-Nutrition
3 Service de chirurgie digestive et endocrinienne, et Laboratoire d’anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims
4 Laboratoire d’anatomie et cytologie pathologique, Hôpital Robert Debré, CHU de Reims
5 Département de Médecine Nucléaire, Institut Jean Godinot
6 Laboratoire de Biophysique, UFR de Médecine
7 CRESTIC - Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804
Abstract : A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. 99mTc-pertechnetate and 99mTc-sestaMIBI dual tracer scintigraphy displayed a mild focal uptake in the projection of the right thyroid lobe with negative ultrasonography. 18F-Fluorocholine PET/CT was quickly performed considering this discrepancy and not only confirmed the scintigraphic findings but also revealed a second contralateral focus of increased uptake, both later confirmed by operative consideration (the two other parathyroid glands are considered normal by the surgeon), pathology, and intraoperative parathyroid hormone assessment.
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Submitted on : Monday, June 25, 2018 - 9:25:16 AM
Last modification on : Wednesday, August 29, 2018 - 1:12:01 PM

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Paul Lalire, Sang Ly, Sophie Deguelte, Martine Patey, David Morland. Incremental value of 18F-fluorocholine PET/CT in the localization of double parathyroid adenomas. Clinical Nuclear Medicine, Lippincott, Williams & Wilkins, 2017, 42 (3), pp.218-220. ⟨hal-01822388⟩

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