Linear association between social anxiety symptoms and neural activations to angry faces: From subclinical to clinical levels

Arnaud Carre; Fabien Gierski; Cedric Lemogne; Eric Tran; Delphine Raucher-Chéné; Céline Béra-Potelle; Christophe Portefaix; Arthur Kaladjian; Laurent Pierot; Chrystel Besche-Richard; Frédéric Limosin

Linear association between social anxiety symptoms and neural activations to angry faces: From subclinical to clinical levels

Arnaud Carre ^{1, 2, 3} Fabien Gierski ^{1, 2, 3, 4} Cedric Lemogne ^{5, 6, 7} Eric Tran ⁴ Delphine Raucher-Chéné ^{1, 3, 4} Céline Béra-Potelle ⁴ Christophe Portefaix ^{2, 3, 8} Arthur Kaladjian ^{1, 3, 4} Laurent Pierot ² Chrystel Besche-Richard ^{1, 3, 9} Frédéric Limosin ^{5, 6, 7}

1 C2S - Cognition, Santé, Société - EA

2 Centre Hospitalier Universitaire de Reims, Hôpital Maison Blanche, Pôle Imagerie, 51100 Reims, France

3 SFR CAP Santé (Champagne-Ardenne Picardie Santé)

4 Centre Hospitalier Universitaire de Reims, Hôpital Robert Debré, Pôle de Psychiatrie Adulte, 51100 Reims, France

5 UPD5 Médecine - Université Paris Descartes - Faculté de Médecine

6 Assistance Publique-Hôpitaux de Paris, Service de Psychiatrie de l’Adulte et du Sujet Âgé, Hôpitaux Universitaires Paris Ouest, 92130 Issy-Les-Moulineaux, Paris, France

7 U894 / UMS 1266 - Institut de psychiatrie et neurosciences

8 CRESTIC - Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804

9 Institut Universitaire de France, 75005 Paris, France

Abstract : Social anxiety disorder (SAD), which is characterized by the fear of being rejected and negatively evaluated, involves altered brain activation dur ing the processing of negative emotions in a social context. Although associated temperament traits, such as shyness or behavioral inhibition, have been studied, there is still insufficient knowledge to support the dimensional approach, which assumes a continuum from subclinical to clinical levels of social anxiety symptoms. This study used functional magnetic resonance imaging (fMRI) to examine the neural bases of individual differences in social anxiety. Our sample included participants with both healthy/subclinical as well as clinical levels of social anxiety. Forty-six participants with a wide range of social anxiety levels performed a gender decision task with emotional facial expressions during fMRI scanning. Activation in the left anterior insula and right lateral prefrontal cortex in response to angry faces was positively correlated with the level of social anxiety in a regression analysis. The results substantiate, with a dimensional approach, those obtained in previous studies that involved SAD patients or healthy and subclinical participants. It may help to refine further therapeutic strategies based on markers of social anxiety.

Document type :

Journal articles

Domain :

Cognitive science / Neuroscience

Complete list of metadatas

https://hal.univ-reims.fr/hal-01822518
Contributor : Nicolas Passat <>
Submitted on : Monday, June 25, 2018 - 11:37:18 AM
Last modification on : Friday, May 10, 2019 - 9:52:40 AM

Linear association between social anxiety symptoms and neural activations to angry faces: From subclinical to clinical levels

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Linear association between social anxiety symptoms and neural activations to angry faces: From subclinical to clinical levels

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