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Interactions of sugar-based bolaamphiphiles with biomimetic systems of plasma membranes

Abstract : Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became interesting for the development of efficient and low cost lipid-based drug delivery systems. Their activity seems to be closely related to their interactions with the lipid components of the plasma membrane of target cells. Despite many works devoted to the chemical synthesis and characterization of sugar-based bolaamphiphiles, their interactions with plasma membrane have not been completely elucidated. In this work, two sugar-based bolaamphiphiles differing only at the level of their sugar residues were chemically synthetized. Their interactions with membranes have been investigated using model membranes containing or not sterol and with in silico approaches. Our findings indicate that the nature of sugar residues has no significant influence for their membrane interacting properties, while the presence of sterol attenuates the interactions of both bolaamphiphiles with the membrane systems. The understanding of this distinct behavior of bolaamphiphiles towards sterol-containing membrane systems could be useful for their applications as drug delivery systems.
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Submitted on : Thursday, July 5, 2018 - 4:50:24 PM
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Mehmet Nail Nasir, Jean-Marc Crowet, Laurence Lins, Firmin Obounou Akong, Arnaud Haudrechy, et al.. Interactions of sugar-based bolaamphiphiles with biomimetic systems of plasma membranes. Biochimie, Elsevier, 2016, 130, pp.23 - 32. ⟨10.1016/j.biochi.2016.04.001⟩. ⟨hal-01831195⟩



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