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Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum

Abstract : A new pentacyclic triterpenoid glucoside, together with fourteen known compounds, was isolated from the roots of Combretum racemosum. Combretaceae). The structure of the new compound was established as 28-O-β-d-glucopyranosyl-2α,3β,21β,23-tetrahydroxyolean-18-en-28-oate (1) on the basis of detailed spectroscopic data including MS, 1D, and 2D NMR. The inhibitory activity of compounds 1–15 against promyelocytic leukemia HL-60 and human erythromyeloblastoid leukemia K562 cell lines was evaluated. Compounds 11 (3-O-β-acetyl-ursolic acid), 14 (betulinic acid), and 15 (quadranoside II) exhibited significant cytotoxicity, with IC50 values of 13 to 50 μM. Among the isolated triterpenes, compounds 1, 3 (arjungenin), 5 (terminolic acid), and 11 exhibited moderate antibacterial activity against Staphylococcus aureus, Escherichia coli and Enterococcus faecalis (MICs within a range of 64 and 256 μg/mL).
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Submitted on : Thursday, October 28, 2021 - 5:39:45 PM
Last modification on : Friday, August 5, 2022 - 11:24:55 AM
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Diane Patricia Apie Gossan, Abdulmagid Alabdul Magid, Philomène Akoua Yao-Kouassi, Jérôme Josse, Sophie C. Gangloff, et al.. Antibacterial and cytotoxic triterpenoids from the roots of Combretum racemosum. Fitoterapia, Elsevier, 2016, 110, pp.89 - 95. ⟨10.1016/j.fitote.2016.03.002⟩. ⟨hal-01833994⟩



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