A new sulfonylated flavonoid and other bioactive compounds isolated from the aerial parts of Cotula anthemoides L.

Wafa Tadrent 1 Abdulmagid Alabdul Magid 2 Ahmed Kabouche 1 Dominique Harakat 2 Laurence Voutquenne-Nazabadioko 2 Zahia Kabouche 1
1 UMC - Université Mentouri Constantine [Algérie]
2 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
Abstract : A new sulfonyl flavonol glucoside, 5,7,4′,5′-tetrahydoxyflavonol 2′-[propanoic acid-(2″′-acetoxy-1″′-sulfonyl)]-5′-O-β-d-glucopyranoside (1) was isolated from the aerial parts of Cotula anthemoides L. in addition to 15 known compounds (2–16). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D-, 2D-NMR and HR-ESI-MS techniques and by comparing their NMR data with those reported in the literature. These compounds were evaluated for their DPPH radical scavenging and tyrosinase inhibitory activity. Compound 6 showed a high DPPH radical scavenging with EC50 value of 9.1 ± 0.4 μM. Compound 11, 9 and 1 exhibited a mild tyrosinase inhibitory activity with IC50 values of 85 ± 0.8, 95 ± 1.5 and 100 ± 0.5 μM, respectively.
Keywords : Cotula anthemoides Asteraceae antioxidant activity tyrosinase inhibitory activity
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Journal articles
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https://hal.univ-reims.fr/hal-01834071
Contributor : Abdulmagid Alabdul Magid <>
Submitted on : Tuesday, July 10, 2018 - 11:05:47 AM
Last modification on : Tuesday, December 17, 2019 - 11:35:45 AM

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Wafa Tadrent, Abdulmagid Alabdul Magid, Ahmed Kabouche, Dominique Harakat, Laurence Voutquenne-Nazabadioko, et al.. A new sulfonylated flavonoid and other bioactive compounds isolated from the aerial parts of Cotula anthemoides L.. Natural Product Research, Taylor & Francis, 2016, 31 (12), pp.1437 - 1445. ⟨10.1080/14786419.2016.1261342⟩. ⟨hal-01834071⟩

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