Triterpene glycosides from the aerial parts of Gouania longipetala

Six previously undescribed triterpenoid saponins, gouaniaside I-VI, were isolated from the aerial parts of Gouania longipetala Hemsl. (Rhamnaceae), in addition to four known triterpenes. The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D- and 2D-NMR and HR-ESI-MS techniques. The inhibitory activity of isolated compounds against promyelocytic leukemia HL60 and human erythromyeloblastoid leukemia K562 cell lines was evaluated and jujuboside I exhibited moderate cytotoxicity, with IC50 values of 13.5 and 21.0 μM, respectively. Among the isolated triterpenes, alphitolic acid exhibited moderate antibacterial activity against Staphylococcus aureus, Enterococcus faecalis and Escherichia coli (MICs 32, 64 and 128 μg/mL, respectively).

Mots clés

Gouania longipetala Rhamnaceae Triterpenoids Antibacterial activity Cytotoxic activity

Domaines

Chimie

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Triterpene glycosides from the aerial parts of Gouania longipetala.pdf (545.56 Ko)

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https://hal.univ-reims.fr/hal-01834083

Soumis le : vendredi 5 novembre 2021-14:09:11

Dernière modification le : lundi 22 avril 2024-09:38:04

Archivage à long terme le : dimanche 6 février 2022-18:55:46

Dates et versions

hal-01834083 , version 1 (05-11-2021)

Identifiants

HAL Id : hal-01834083 , version 1
DOI : 10.1016/j.phytochem.2016.11.004

Citer

Diane Patricia Apie Gossan, Abdulmagid Alabdul Magid, Philomène Akoua Yao-Kouassi, Antoine Ahibo Coffy, Jérôme Josse, et al.. Triterpene glycosides from the aerial parts of Gouania longipetala. Phytochemistry, 2017, 134, pp.71 - 77. ⟨10.1016/j.phytochem.2016.11.004⟩. ⟨hal-01834083⟩

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