M. Cross, E. Smith, D. Hoy, S. Nolte, I. Ackerman et al., The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study, Ann Rheum Dis, vol.73, issue.7, pp.1323-1353, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01809208

J. W. Bijlsma, F. Berenbaum, and F. P. Lafeber, Osteoarthritis: an update with relevance for clinical practice, Lancet, vol.377, issue.9783, pp.2115-2141, 2011.

A. Courties, O. Gualillo, F. Berenbaum, and J. Sellam, Metabolic stress-induced joint inflammation and osteoarthritis, Osteoarthr Cartil, vol.23, issue.11, pp.1955-65, 2015.
DOI : 10.1016/j.joca.2015.05.016

URL : https://hal.archives-ouvertes.fr/hal-01159318

K. Mcculloch, G. J. Litherland, and T. S. Rai, Cellular senescence in osteoarthritis pathology, Aging Cell, vol.16, issue.2, pp.210-218, 2017.

M. Rahmati, G. Nalesso, A. Mobasheri, and M. Mozafari, Aging and osteoarthritis: central role of the extracellular matrix, Ageing Res Rev, 2017.

L. Tardio, J. Andrés-bergos, N. E. Zachara, L. Herrerobeaumont, and G. , N-acetylglucosamine (O-GlcNAc) protein modification is increased in the cartilage of patients with knee osteoarthritis, Osteoarthr Cartil, vol.22, issue.2, pp.259-63, 2014.

N. Verzijl, J. Degroot, E. Oldehinkel, R. A. Bank, S. R. Thorpe et al., Age-related accumulation of Maillard reaction products in human articular cartilage collagen, Biochem J, vol.350, issue.2, pp.381-388, 2000.

P. Gillery and S. Jaisson, Post-translational modification derived products (PTMDPs): toxins in chronic diseases?, Clin Chem Lab Med, vol.52, issue.1, pp.33-41, 2014.

N. Ahmed and P. J. Thornalley, Advanced glycation endproducts: what is their relevance to diabetic complications?, Diabetes Obes Metab, vol.9, issue.3, pp.233-278, 2007.

N. Verzijl, J. Degroot, Z. C. Ben, O. Brau-benjamin, A. Maroudas et al., Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis, Arthritis Rheum, vol.46, issue.1, pp.114-137, 2002.

C. Y. Huang, K. Y. Lai, L. F. Hung, W. L. Wu, F. C. Liu et al., Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes, Rheumatology, vol.50, issue.8, pp.1379-89, 2011.

D. M. Saudek and J. Kay, Advanced glycation end-products and osteoarthritis, Curr Rheumatol Rep, vol.5, issue.1, pp.33-40, 2003.

Z. Rasheed, N. Akhtar, and T. M. Haqqi, Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor-?B in human osteoarthritis chondrocytes, Rheumatology (Oxford), vol.50, issue.5, pp.838-51, 2011.

C. Legrand, C. Ahmed, A. Anwar, K. Rajpoot, S. Pasha et al., Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo, Arthritis Res Ther, vol.20, p.131, 2018.

P. A. Vos, S. C. Mastbergen, A. M. Huisman, T. N. De-boer, J. Degroot et al., In end stage osteoarthritis, cartilage tissue pentosidine levels are inversely related to parameters of cartilage damage, Osteoarthr Cartil, vol.20, issue.3, pp.233-273, 2012.

J. Hirose, S. Yamabe, K. Takada, N. Okamoto, R. Nagai et al., Immunohistochemical distribution of advanced glycation end products (AGEs) in human osteoarthritic cartilage, Acta Histochem, vol.113, issue.6, pp.613-621, 2011.

W. Schwab, U. Friess, U. Hempel, E. Schulze, Z. Makita et al., Immunohistochemical demonstration of-(carboxymethyl)lysine protein adducts in normal and osteoarthritic cartilage, Histochem Cell Biol, vol.117, issue.6, pp.541-547, 2002.

H. D. Dakin and H. W. Dudley, An enzyme concerned with the formation of hydroxy acids from ketonic aldehydes, J Biol Chem, vol.14, pp.155-162, 1913.

N. Rabbani and P. J. Thornalley, Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome, Amino Acids, vol.42, issue.4, pp.1133-1175, 2012.

M. Xue, N. Rabbani, and P. J. Thornalley, Glyoxalase in ageing, Semin Cell Dev Biol, vol.22, issue.3, pp.293-301, 2011.
DOI : 10.1016/j.semcdb.2011.02.013

S. Radjei, M. Gareil, M. Moreau, E. Leblanc, S. Schnebert et al., The glyoxalase enzymes are differentially localized in epidermis and regulated during ageing and photoageing, Exp Dermatol, vol.25, issue.6, pp.492-496, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01544053

M. Morcos, X. Du, F. Pfisterer, H. Hutter, A. A. Sayed et al., Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans, Aging Cell, vol.7, issue.2, pp.260-269, 2008.

M. Xue, M. O. Weickert, S. Qureshi, N. B. Kandala, A. Anwar et al., Improved glycemic control and vascular function in overweight and obese subjects by glyoxalase 1 inducer formulation, Diabetes, vol.65, issue.8, pp.2282-94, 2016.

U. Ahmed, P. J. Thornalley, and N. Rabbani, Possible role of methylglyoxal and glyoxalase in arthritis, Biochem Soc Trans, vol.42, issue.2, pp.538-580, 2014.

C. Franceschi, M. Bonafè, S. Valensin, F. Olivieri, D. Luca et al., Inflamm-aging. An evolutionary perspective on immunosenescence, Ann N Y Acad Sci, vol.908, pp.244-54, 2000.

R. F. Loeser, J. A. Collins, and B. O. Diekman, Ageing and the pathogenesis of osteoarthritis, Nat Rev Rheumatol, vol.12, issue.7, pp.412-432, 2016.

C. Franceschi and J. Campisi, Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases, J Gerontol A Biol Sci Med Sci, vol.69, issue.1, pp.4-9, 2014.

M. Michaud, L. Balardy, G. Moulis, C. Gaudin, C. Peyrot et al., Proinflammatory cytokines, aging, and age-related diseases, J Am Med Dir Assoc, vol.14, issue.12, pp.877-82, 2013.

R. Varadhan, W. Yao, A. Matteini, B. A. Beamer, Q. L. Xue et al., Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults, J Gerontol A Biol Sci Med Sci, vol.69, issue.2, pp.165-73, 2014.

C. R. Scanzello, Role of low-grade inflammation in osteoarthritis, Curr Opin Rheumatol, vol.29, issue.1, pp.79-85, 2017.

P. Van-der-kraan, C. Matta, and A. Mobasheri, Age-related alterations in signaling pathways in articular chondrocytes: implications for the pathogenesis and progression of osteoarthritis-a mini-review, Gerontology, vol.63, issue.1, pp.29-35, 2017.

M. Attur, A. Ben-artzi, Q. Yang, A. He, H. J. Worman et al., Perturbation of nuclear lamin A causes cell death in chondrocytes, Arthritis Rheum, vol.64, issue.6, pp.1940-1949, 2012.

M. Attur, S. Krasnokutsky, A. Statnikov, J. Samuels, Z. Li et al., Lowgrade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers, Arthritis Rheumatol, vol.67, issue.11, pp.2905-2906, 2015.

G. Livshits, G. Zhai, D. J. Hart, B. S. Kato, H. Wang et al., Interleukin-6 is a significant predictor of radiographic knee osteoarthritis: the Chingford study, Arthritis Rheum, vol.60, issue.7, pp.2037-2082, 2009.

T. D. Spector, D. J. Hart, D. Nandra, D. V. Doyle, N. Mackillop et al., Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease, Arthritis Rheum, vol.40, issue.4, pp.723-730, 1997.

C. B. Forsyth, A. Cole, G. Murphy, J. L. Bienias, H. J. Im et al., Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli, J Gerontol A Biol Sci Med Sci, vol.60, issue.9, pp.1118-1142, 2005.

M. C. Laiguillon, A. Courties, X. Houard, M. Auclair, A. Sautet et al., Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis, Osteoarthr Cartil, vol.23, issue.9, pp.1513-1535, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01153393

G. E. Mann, J. R. David, F. Li, P. De-winter, and R. C. Siow, Activation of endothelial nitric oxide synthase by dietary isoflavones: role of NO in Nrf-2-mediated antioxidant gene expression, Cardiovasc Res, vol.75, issue.2, pp.261-74, 2007.

M. Xue, N. Rabbani, H. Momiji, P. Imbasi, M. M. Anwar et al., Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation, Biochem J, vol.443, issue.1, pp.213-235, 2012.

J. M. Bohlender, S. Franke, G. Stein, and G. Wolf, Advanced glycation end products and the kidney, Am J Physiol Renal Physiol, vol.289, issue.4, pp.645-59, 2005.

M. Gosset, F. Berenbaum, S. Thirion, and C. Jacques, Primary culture and phenotyping of murine chondrocytes, Nat Protoc, vol.3, issue.8, pp.1253-60, 2008.

C. Salvat, A. Pigenet, L. Humbert, F. Berenbaum, and S. Thirion, Immature murine articular chondrocytes in primary culture: a new tool for investigating cartilage, Osteoarthr Cartil, vol.13, issue.3, pp.243-252, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00017735

Z. El-ali, C. Gerbeix, P. Hemon, P. R. Esser, S. F. Martin et al., Allergic skin inflammation induced by chemical sensitizers is controlled by the transcription factor Nrf2, Toxicol Sci, vol.134, issue.1, pp.39-48, 2013.

C. Vaamonde-garcia, A. Courties, A. Pigenet, M. C. Laiguillon, A. Sautet et al., The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes-associated osteoarthritis, J Biol Chem, vol.292, issue.35, pp.14505-14520, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01614932

M. Kerkeni, S. Weiss, I. Jaisson, S. Dandana, A. Addad et al., Increased serum concentrations of pentosidine are related to presence and severity of coronary artery disease, Thromb Res, vol.134, issue.3, pp.633-641, 2014.

S. Jaisson, P. F. Souchon, A. Desmons, A. S. Salmon, B. Delemer et al., Early formation of serum advanced glycation end-products in children with type 1 diabetes mellitus: relationship with glycemic control, J Pediatr, vol.172, pp.56-62, 2016.

N. Rabbani and P. J. Thornalley, Glyoxalase in diabetes, obesity and related disorders, Semin Cell Dev Biol, vol.22, issue.3, pp.309-326, 2011.

C. E. Aubert, P. L. Michel, P. Gillery, S. Jaisson, M. Fonfrede et al., Association of peripheral neuropathy with circulating advanced glycation end products, soluble receptor for advanced glycation end products and other risk factors in patients with type 2 diabetes, Diabetes Metab Res Rev, vol.30, issue.8, pp.679-85, 2014.

C. Ma, Y. Zhang, Y. Q. Li, C. Chen, W. Cai et al., The role of PPAR? in advanced glycation end products-induced inflammatory response in human chondrocytes, PLoS One, vol.10, issue.5, p.125776, 2015.

P. J. Thornalley, A. Langborg, and H. S. Minhas, Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose, Biochem J, vol.344, pp.109-125, 1999.

O. W. Griffith and R. G. Kilbourn, Nitric oxide synthase inhibitors: amino acids, Methods Enzymol, vol.268, pp.375-92, 1996.

S. Dikalov, Cross talk between mitochondria and NADPH oxidases, Free Radic Biol Med, vol.51, issue.7, pp.1289-301, 2011.

A. G. Miller, D. G. Smith, M. Bhat, and R. H. Nagaraj, Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions, J Biol Chem, vol.281, issue.17, pp.11864-71, 2006.

G. H. Liu, J. Qu, and X. Shen, NF-kappaB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK, Biochim Biophys Acta, vol.1783, issue.5, pp.713-740, 2008.

S. Ranganathan, P. J. Ciaccio, and E. S. Walsh, Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation, Gene, vol.240, issue.1, pp.149-55, 1999.

C. Tonelli, I. Chio, and D. A. Tuveson, Transcriptional regulation by Nrf2, Antioxid Redox Signal, 2017.

J. Wang, G. Wang, and G. W. Sun, Role of PPAR? in down-regulating AGE-induced TGF-? and MMP-9 expressions in chondrocytes, Genet Mol Res, vol.15, issue.2, 2016.

M. D. Carlo and R. F. Loeser, Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels, Arthritis Rheum, vol.48, issue.12, pp.3419-3449, 2003.