Melantheraside A–E, five original triterpenes with natural chloride or oxime group from the aerial parts of Melanthera elliptica O. Hoffm.

Abstract : Five new pentacyclic triterpenoids, Melantheraside A–E (1–5) together with eleven known compounds (6-16) were isolated from the methanol extract of the aerial parts of Melanthera elliptica O. Hoffm. Their structures were established by extensive analysis of 1D- (1H, 13C), 2D- (COSY, ROESY, HSQC and HMBC) NMR data experiments in conjunction with mass spectrometry (TOFESIMS and HR-TOFESIMS) and by comparison with data reported in the literature. The structures of the new compounds were established as: 12α-chloro-3β-hydroxyoleanan-28,13β-olide (1), 3β-acetoxy-12α-hydroxytaraxer-14-en-28-oic acid (2), 3β-hydroxy-12-oximetaraxeran-28,14β-olide (3), 3β-acetoxy-12-oximetaraxeran-28,14β-olide (4) and 2β-carboxyamino-12α-chloro-3-oxo-1-nor-oleanan-28,13β-olide (5). The 3β-acetoxy-12α-chloro-oleanan-28,13β-olide (6) was isolated for the first time as natural product.
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https://hal.univ-reims.fr/hal-01996059
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Submitted on : Monday, January 28, 2019 - 10:27:43 AM
Last modification on : Tuesday, December 17, 2019 - 10:08:27 AM

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Cyrille Ngoufack Tagousop, David Ngnokam, Dominique Harakat, Laurence Voutquenne-Nazabadioko. Melantheraside A–E, five original triterpenes with natural chloride or oxime group from the aerial parts of Melanthera elliptica O. Hoffm.. Phytochemistry Letters, Elsevier, 2018, 26, pp.38-43. ⟨10.1016/j.phytol.2018.05.007⟩. ⟨hal-01996059⟩

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