Triterpenoids from the leaves of Alphitonia xerocarpus Baill and their biological activity - Université de Reims Champagne-Ardenne Access content directly
Journal Articles Phytochemistry Year : 2016

Triterpenoids from the leaves of Alphitonia xerocarpus Baill and their biological activity

Abstract

Ten previously undescribed triterpenoid saponins and a previously undescribed norlupane triterpenoid were isolated, with three known saponins, four known flavonoids, two known lupane derivatives, sitosterol and 6'-heptadecanoyl-3-O-β-d-glucopyranosylsitosterol from the leaves of Alphitonia xerocarpus (Rhamnaceae), an endemic tree of New Caledonia. The chemical structures of the purified compounds were identified by nuclear magnetic resonance and mass spectrometry. The isolated compounds were tested for their antioxidant, antityrosinase, antibacterial and cytotoxic activity. The aqueous methanol extract showed antioxidant activity (DPPH assay) due to the presence of rutin. Ceanothenic acid showed good cytotoxic activity against a KB cell line (IC50 = 2.6 μM) and antibacterial activity against Staphylococcus aureus and Enterococcus faecalis with MIC values of 8 and 16 μg/mL, respectively. The previously undescribed 29-hydroxyceanothenic acid exhibited moderate cytotoxic activity (IC50 = 10 μM), good antibacterial activity against S. aureus (MIC = 4 μg/mL) and moderate antibacterial activity against E. faecalis (MIC = 16 μg/mL).
Fichier principal
Vignette du fichier
Publi feuilles Alphitonia xerocarpus manuscrit_PhytoSecondRevised_HAL.pdf (1.6 Mo) Télécharger le fichier
Publi feuilles Alphitonia xerocarpus suplementary material_Rev.pdf (3.96 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-01996335 , version 1 (28-10-2021)

Licence

Attribution - NonCommercial - NoDerivatives

Identifiers

Cite

Dima Muhammad, Nathalie Lalun, Hélène Bobichon, Elisabeth Le Magrex Debar, Sophie C. Gangloff, et al.. Triterpenoids from the leaves of Alphitonia xerocarpus Baill and their biological activity. Phytochemistry, 2016, 129, pp.45-57. ⟨10.1016/j.phytochem.2016.07.005⟩. ⟨hal-01996335⟩
69 View
64 Download

Altmetric

Share

Gmail Facebook X LinkedIn More