Structure-Activity Relationships of Haemolytic Saponins - Archive ouverte HAL Access content directly
Journal Articles Pharmaceutical biology Year : 2002

Structure-Activity Relationships of Haemolytic Saponins

(1) , (1) , (1) , (2)
1
2

Abstract

The haemolytic activity of 59 samples, natural or partially synthetic pure saponins and mixtures thereof, was determined. The tested saponins possessed triterpenic genins and six structural skeleton types were studied. Structure-activity relationships were established by comparison of the functional groups of each saponin and of the branched sugar chains attached to aglycone. The haemolytic activity is shown to depend on the number of sugar units in the chains, as well as on the presence of an osidic chain in position 3 or of functional groups on the genin such as carboxylic or 16a-OH. Comparison of activities of monodesmosidic and bidesmosidic saponins showed that monodesmosidic saponins were generally more active and suggested a polar balance between the two sugar chains at positions 3 and 28. Twelve saponins showed strong haemolytic activity and five possessed a Haemolytic Index (HI) greater than 100,000, such as the a- and ß-aescines (HI: 200,000).
Fichier principal
Vignette du fichier
Structure activity of saponins_Hal.pdf (472.3 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-01996982 , version 1 (24-09-2021)

Licence

Attribution - NonCommercial - CC BY 4.0

Identifiers

Cite

Laurence Voutquenne, Catherine Lavaud, Georges Massiot, Louisette Le Men-Olivier. Structure-Activity Relationships of Haemolytic Saponins. Pharmaceutical biology, 2002, 40 (4), pp.253-262. ⟨10.1076/phbi.40.4.253.8470⟩. ⟨hal-01996982⟩
51 View
48 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More