Monitoring Radiotherapeutic Response in Prostate Cancer Patients Using High Throughput FTIR Spectroscopy of Liquid Biopsies - Archive ouverte HAL Access content directly
Journal Articles Cancers Year : 2019

Monitoring Radiotherapeutic Response in Prostate Cancer Patients Using High Throughput FTIR Spectroscopy of Liquid Biopsies

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Dinesh K.R. Medipally
  • Function : Author
Thi Nguyet Que Nguyen
  • Function : Author
Jane Bryant
  • Function : Author
Emma Noone
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Shirley Bradshaw
  • Function : Author
Marie Finn
  • Function : Author
Mary Dunne
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Aoife Shannon
  • Function : Author
John Armstrong
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Fiona Lyng
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  • PersonId : 964832
Aidan Meade
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Abstract

Radiation therapy (RT) is used to treat approximately 50% of all cancer patients. However, RT causes a wide range of adverse late effects that can affect a patient's quality of life. There are currently no predictive assays in clinical use to identify patients at risk of normal tissue radiation toxicity. This study aimed to investigate the potential of Fourier transform infrared (FTIR) spectroscopy for monitoring radiotherapeutic response. Blood plasma was acquired from 53 prostate cancer patients at five different time points: prior to treatment, after hormone treatment, at the end of radiotherapy, two months post radiotherapy and eight months post radiotherapy. FTIR spectra were recorded from plasma samples at all time points and the data was analysed using MATLAB software. Discrimination was observed between spectra recorded at baseline versus follow up time points, as well as between spectra from patients showing minimal and severe acute and late toxicity using principal component analysis. A partial least squares discriminant analysis model achieved sensitivity and specificity rates ranging from 80% to 99%. This technology may have potential to monitor radiotherapeutic response in prostate cancer patients using non-invasive blood plasma samples and could lead to individualised patient radiotherapy.

Dates and versions

hal-02310323 , version 1 (10-10-2019)

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Dinesh K.R. Medipally, Thi Nguyet Que Nguyen, Jane Bryant, Valérie Untereiner, Ganesh Sockalingum, et al.. Monitoring Radiotherapeutic Response in Prostate Cancer Patients Using High Throughput FTIR Spectroscopy of Liquid Biopsies. Cancers, 2019, 11 (7), pp.925. ⟨10.3390/cancers11070925⟩. ⟨hal-02310323⟩
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