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New insights into spectral histopathology: infrared-based scoring of tumour aggressiveness of squamous cell lung carcinomas

Abstract : Spectral histopathology, based on infrared interrogation of tissue sections, proved a promising tool for helping pathologists in characterizing histological structures in a quantitative and automatic manner. In cancer diagnosis, the use of chemometric methods permits establishing numerical models able to detect cancer cells and to characterize their tissular environment. In this study, we focused on exploiting multivariate infrared data to score the tumour aggressiveness in preneoplastic lesions and squamous cell lung carcinomas. These lesions present a wide range of aggressive phenotypes; it is also possible to encounter cases with various degrees of aggressiveness within the same lesion. Implementing an infrared-based approach for a more precise histological determination of the tumour aggressiveness should arouse interest among pathologists with direct benefits for patient care. In this study, the methodology was developed from a set of samples including all degrees of tumour aggressiveness and by constructing a chain of data processing steps for an automated analysis of tissues currently manipulated in routine histopathology.
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https://hal.univ-reims.fr/hal-02310329
Contributor : Brigitte PERRON Connect in order to contact the contributor
Submitted on : Thursday, October 10, 2019 - 9:45:48 AM
Last modification on : Friday, August 5, 2022 - 11:21:52 AM

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Vincent Gaydou, Myriam C. Polette, Cyril Gobinet, Claire Kileztky, Jean-François Angiboust, et al.. New insights into spectral histopathology: infrared-based scoring of tumour aggressiveness of squamous cell lung carcinomas. Chemical Science , The Royal Society of Chemistry, 2019, 10 (15), pp.4246-4258. ⟨10.1039/c8sc04320e⟩. ⟨hal-02310329⟩

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