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Triterpene saponins from the roots of Parkia bicolor A. Chev

Michel Boni Bitchi Abdulmagid Alabdul-Magid 1 Philomène Akoua Yao-Kouassi Faustin Aka Kabran Dominique Harakat 1 Agathe Martinez 1 Hamid Morjani 2 Félix Zanahi Tonzibo Laurence Voutquenne-Nazabadioko 1
1 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
2 BIOSPECT - Biospectroscopie Translationnelle - EA 7506
Abstract : Five undescribed triterpene-type saponins, parkibicolorosides A–E, a cassane-type diterpene, and a known trimethoxy benzene glucoside were isolated from the roots of Parkia bicolor A. Chev. Their structures were elucidated by different spectroscopic methods including 1D- and 2D-NMR experiments as well as HR-ESI-MS analysis. Their cytotoxic activity against the chronic myeloid leukemia (K562) cell line was evaluated. The monosaccharides saponins exhibited a moderate antiproliferative activity with IC50 ranging from 48.49 ± 0.16 to 81.66 ± 0.17 μM.
Keywords : Diterpene Triterpenoid saponins Fabaceae Cytotoxic activity Parkia bicolor
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https://hal.univ-reims.fr/hal-02310366
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Submitted on : Friday, September 24, 2021 - 10:50:40 AM
Last modification on : Tuesday, January 4, 2022 - 6:44:47 AM

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URCA | CNRS | BIOSPECT | ICMR | INC-CNRS | U-PICARDIE

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Michel Boni Bitchi, Abdulmagid Alabdul-Magid, Philomène Akoua Yao-Kouassi, Faustin Aka Kabran, Dominique Harakat, et al.. Triterpene saponins from the roots of Parkia bicolor A. Chev. Fitoterapia, Elsevier, 2019, 137, pp.104264. ⟨10.1016/j.fitote.2019.104264⟩. ⟨hal-02310366⟩

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