Triterpene saponins from the roots of Parkia bicolor A. Chev
Abstract
Five undescribed triterpene-type saponins, parkibicolorosides A–E, a cassane-type diterpene, and a known trimethoxy benzene glucoside were isolated from the roots of Parkia bicolor A. Chev. Their structures were elucidated by different spectroscopic methods including 1D- and 2D-NMR experiments as well as HR-ESI-MS analysis. Their cytotoxic activity against the chronic myeloid leukemia (K562) cell line was evaluated. The monosaccharides saponins exhibited a moderate antiproliferative activity with IC50 ranging from 48.49 ± 0.16 to 81.66 ± 0.17 μM.
Domains
Physics [physics] Physics [physics] Biological Physics [physics.bio-ph] Life Sciences [q-bio] Biochemistry, Molecular Biology Biophysics Life Sciences [q-bio] Cellular Biology Subcellular Processes [q-bio.SC] Life Sciences [q-bio] Cancer Engineering Sciences [physics] Optics / Photonic Engineering Sciences [physics] Signal and Image processing Life Sciences [q-bio] Cellular Biology Cell Behavior [q-bio.CB]
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