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Journal Articles Fitoterapia Year : 2019

Triterpene saponins from the roots of Parkia bicolor A. Chev

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Abstract

Five undescribed triterpene-type saponins, parkibicolorosides A–E, a cassane-type diterpene, and a known trimethoxy benzene glucoside were isolated from the roots of Parkia bicolor A. Chev. Their structures were elucidated by different spectroscopic methods including 1D- and 2D-NMR experiments as well as HR-ESI-MS analysis. Their cytotoxic activity against the chronic myeloid leukemia (K562) cell line was evaluated. The monosaccharides saponins exhibited a moderate antiproliferative activity with IC50 ranging from 48.49 ± 0.16 to 81.66 ± 0.17 μM.
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Dates and versions

hal-02310366 , version 1 (24-09-2021)

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Michel Boni Bitchi, Abdulmagid Alabdul-Magid, Philomène Akoua Yao-Kouassi, Faustin Aka Kabran, Dominique Harakat, et al.. Triterpene saponins from the roots of Parkia bicolor A. Chev. Fitoterapia, 2019, 137, pp.104264. ⟨10.1016/j.fitote.2019.104264⟩. ⟨hal-02310366⟩
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