Elastin-Derived Peptides Are New Regulators of Thrombosis

Abstract : Elastin is the major structural extracellular matrix component of the arterial wall that provides the elastic recoil properties and resilience essential for proper vascular function. Elastin-derived peptides (EDP) originating from elastin fragmentation during vascular remodeling have been shown to play an important role in cell physiology and development of cardiovascular diseases. However, their involvement in thrombosis has been unexplored to date. In this study, we investigated the effects of EDP on (1) platelet aggregation and related signaling and (2) thrombus formation. We also characterized the mechanism by which EDP regulate thrombosis.
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https://hal.univ-reims.fr/hal-02331272
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Submitted on : Thursday, October 24, 2019 - 12:42:52 PM
Last modification on : Friday, November 15, 2019 - 10:10:47 AM

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Charlotte Kawecki, Nathalie Hezard, Olivier Bocquet, Gaël Poitevin, Fanja Rabenoelina, et al.. Elastin-Derived Peptides Are New Regulators of Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2014, 34 (12), pp.2570-2578. ⟨10.1161/ATVBAHA.114.304432⟩. ⟨hal-02331272⟩

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