Matrix ageing and vascular impacts: focus on elastin fragmentation

Abstract : Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a major problem of public health. Over the years, life expectancy has considerably increased throughout the world, and the prevalence of CVD is inevitably rising with the growing ageing of the population. The normal process of ageing is associated with progressive deterioration in structure and function of the vasculature, commonly called vascular ageing. At the vascular level, extracellular matrix (ECM) ageing leads to molecular alterations in long half-life proteins, such as elastin and collagen, and have critical effects on vascular diseases. This review highlights ECM alterations occurring during vascular ageing with a specific focus on elastin fragmentation and also the contribution of elastin-derived peptides (EDP) in age-related vascular complications. Moreover, current and new pharmacological strategies aiming at minimizing elastin degradation, EDP generation, and associated biological effects are discussed. These strategies may be of major relevance for preventing and/or delaying vascular ageing and its complications.
Complete list of metadatas

https://hal.univ-reims.fr/hal-02331316
Contributor : Laurent Debelle <>
Submitted on : Thursday, October 24, 2019 - 12:50:53 PM
Last modification on : Friday, November 15, 2019 - 10:10:47 AM

Links full text

Identifiers

Collections

Citation

Laurent Duca, Sébastien Blaise, Béatrice Romier, Muriel Laffargue, Stéphanie Gayral, et al.. Matrix ageing and vascular impacts: focus on elastin fragmentation. Cardiovascular Research, Oxford University Press (OUP), 2016, 110 (3), pp.298-308. ⟨10.1093/cvr/cvw061⟩. ⟨hal-02331316⟩

Share

Metrics

Record views

13