HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Investigating pre‐analytical requirements for serum and plasma based infrared spectro‐diagnostic

Abstract : Radiation therapy (RT) is used to treat approximately 50% of all cancer patients. However, RT causes a wide range of adverse late effects that can affect a patient's quality of life. There are currently no predictive assays in clinical use to identify patients at risk of normal tissue radiation toxicity. This study aimed to investigate the potential of Fourier transform infrared (FTIR) spectroscopy for monitoring radiotherapeutic response. Blood plasma was acquired from 53 prostate cancer patients at five different time points: prior to treatment, after hormone treatment, at the end of radiotherapy, two months post radiotherapy and eight months post radiotherapy. FTIR spectra were recorded from plasma samples at all time points and the data was analysed using MATLAB software. Discrimination was observed between spectra recorded at baseline versus follow up time points, as well as between spectra from patients showing minimal and severe acute and late toxicity using principal component analysis. A partial least squares discriminant analysis model achieved sensitivity and specificity rates ranging from 80% to 99%. This technology may have potential to monitor radiotherapeutic response in prostate cancer patients using non-invasive blood plasma samples and could lead to individualised patient radiotherapy.
Complete list of metadata

Contributor : Brigitte Perron Connect in order to contact the contributor
Submitted on : Thursday, December 12, 2019 - 9:33:09 AM
Last modification on : Tuesday, May 10, 2022 - 3:38:03 PM

Links full text




Lila Lovergne, Jean Lovergne, Pascaline Bouzy, Valérie Untereiner, Marc Offroy, et al.. Investigating pre‐analytical requirements for serum and plasma based infrared spectro‐diagnostic. Journal of Biophotonics, Wiley, 2019, 12 (12), ⟨10.1002/jbio.201900177⟩. ⟨hal-02406330⟩



Record views