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Journal articles
Diastereoselective synthesis and cytotoxic evaluation of new isoxazoles and pyrazoles with monoterpenic skeleton
Abstract : New series of chiral isoxazoles and pyrazoles with monoterpenic skeleton, have been efficiently synthesized from naturally occurring (R)-Carvone, using 1,3-dipolar cycloaddition reaction with arylonitrile oxides and diarylnitrilimines. The reaction showed high peri-, and regioselectivity. In the case of diarylnitrilimines, the reaction revealed to be highly diastereoselective. The structure of the newly synthesized adducts were fully established via spectroscopic analysis and X-ray crystallography. A succinct theoretical study was used to explain the diastereoselectivity experimentally observed. All the newly synthesized monoterpenic isoxazole and pyrazole derivatives were evaluated for their cytotoxic activity against human HT1080, MCF-7 and A-549 cancer cells.
https://hal.univ-reims.fr/hal-02430280
Contributor : Abdelkhalek Riahi Connect in order to contact the contributor
Submitted on : Tuesday, January 7, 2020 - 11:18:57 AM
Last modification on : Tuesday, January 4, 2022 - 6:45:09 AM
Contributor : Abdelkhalek Riahi Connect in order to contact the contributor
Submitted on : Tuesday, January 7, 2020 - 11:18:57 AM
Last modification on : Tuesday, January 4, 2022 - 6:45:09 AM