Pyrroloquinolone A, a new alkaloid and other phytochemicals from Atractylis cancellata L. with antioxidant and anticholinesterase activities

Mohamed Ibrahim Badaoui 1 Abdulmagid Alabdul Magid 2 Mohammed Benkhaled 1 Chawki Bensouici 3 Dominique Harakat 2 Laurence Voutquenne-Nazabadioko 2 Hamada Haba 1
1 LCCE - Laboratoire de Chimie et Chimie de l'Environnement
2 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
3 Centre de Recherche en biotechnologie (CRBt) Constantine
Abstract : A new alkaloid pyrroloquinolone A (1), along with fifteen known compounds 2–16 were isolated from the petroleum ether, EtOAc and n-BuOH extracts of the whole plant Atractylis cancellata L. Their structures were elucidated on the basis of extensive spectroscopic analysis including 1D- and 2D-NMR and HR-ESI-MS techniques. This is the first report of alkaloids in the genus Atractylis. Some of the isolated compounds and extracts were evaluated for their antioxidant potential (scavenging activity of DPPH and ABTS radicals, and reducing Fe+3 and Cu+2 power assays) and acetylcholinesterase and butyrylcholinesterase inhibitory activities. Compounds 8 and 11 showed good antioxidant capacity compared to ascorbic acid, BHA, and BHT used as standards, whereas compounds 1 and 2 exhibited good anticholinesterase activities compared to galantamine used as standard.
Keywords : Asteraceae Atractylis cancellata L pyrroloquinolone A NMR antioxidant activity anticholinesterase activity
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Journal articles
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https://hal.univ-reims.fr/hal-02430930
Contributor : Laurence Voutquenne <>
Submitted on : Tuesday, January 7, 2020 - 4:05:02 PM
Last modification on : Wednesday, January 8, 2020 - 2:02:46 AM

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Mohamed Ibrahim Badaoui, Abdulmagid Alabdul Magid, Mohammed Benkhaled, Chawki Bensouici, Dominique Harakat, et al.. Pyrroloquinolone A, a new alkaloid and other phytochemicals from Atractylis cancellata L. with antioxidant and anticholinesterase activities. Natural Product Research, Taylor & Francis, 2019, pp.1-7. ⟨10.1080/14786419.2019.1682575⟩. ⟨hal-02430930⟩

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