COPD care in the 21st century: a public health priority, Respir Care, vol.63, pp.591-600, 2018. ,
Chronic obstructive pulmonary disease guidelines in Europe: a look into the future, Respir Res, vol.19, p.11, 2018. ,
Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the gold science committee report 2019, Eur Respirat J, 2019. ,
Causes of misdiagnosis of chronic obstructive pulmonary disease: a systematic scoping review, Respir Med, vol.129, pp.63-84, 2017. ,
Small airways disease: time for a revisit?, Int J Chron Obstruct Pulmon Dis, vol.12, pp.2343-53, 2017. ,
Stable COPD treatment: where are we?, COPD, vol.15, pp.123-132, 2018. ,
Current and emerging biologic therapies for asthma and COPD, Respir Care, vol.63, pp.699-707, 2018. ,
Diagnosis and outpatient management of chronic obstructive pulmonary disease: a review, JAMA, vol.321, pp.786-97, 2019. ,
Mechanisms of airway remodeling, Chest, vol.144, pp.1026-1058, 2013. ,
The pathology of small airways disease in COPD: historical aspects and future directions, Respir Res, vol.20, p.49, 2019. ,
Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD), Respir Investig, vol.55, pp.104-117, 2017. ,
Cilia dysfunction in lung disease, Annu Rev Physiol, vol.77, pp.379-406, 2015. ,
Ciliary beating is depressed in nasal cilia from chronic obstructive pulmonary disease subjects, Respir Med, vol.106, pp.1139-1186, 2012. ,
Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes, Eur Respir J, vol.53, pp.2553-2017, 2019. ,
Sonic hedgehog signaling in the lung from development to disease, Am J Respir Cell Mol Biol, vol.52, pp.1-13, 2015. ,
Role of sonic Hedgehog in idiopathic pulmonary fibrosis, Am J Physiol Lung Cell Mol Physiol, vol.303, pp.978-90, 2012. ,
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype, J Clin Invest, vol.128, pp.4343-58, 2018. ,
A highlight on sonic hedgehog pathway, Cell Commun Signal, vol.16, p.11, 2018. ,
Biochemical mechanisms of vertebrate hedgehog signaling, Development, vol.146, 2019. ,
Noncanonical hedgehog signaling is a positive regulator of the WNT pathway and is required for the survival of colon cancer stem cells, Cell Rep, vol.21, pp.2813-2841, 2017. ,
Noncanonical Hedgehog signaling, Vitam Horm, vol.88, pp.55-72, 2012. ,
Canonical sonic hedgehog signaling in early lung development, J Dev Biol, vol.5, 2017. ,
Sonic hedgehog signaling regulates myofibroblast function during alveolar septum formation in murine postnatal lung, Am J Respir Cell Mol Biol, vol.57, pp.280-93, 2017. ,
Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration, Nature, vol.526, pp.578-82, 2015. ,
Hedgehog: the key to maintaining adult lung repair and regeneration, J Cell Commun Signal, vol.11, pp.95-101, 2017. ,
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci, PLoS Genet, vol.5, p.1000421, 2009. ,
Candidate genes for COPD: current evidence and research, Int J Chron Obstruct Pulmon Dis, vol.10, pp.2249-55, 2015. ,
What do polymorphisms tell us about the mechanisms of COPD?, Clin Sci, vol.131, pp.2847-63, 2017. ,
Motile cilia of human airway epithelia contain hedgehog signaling components that mediate noncanonical hedgehog signaling, Proc Natl Acad Sci, vol.115, pp.1370-1375, 2018. ,
Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease, Sci Rep, vol.9, p.3353, 2019. ,
British thoracic society guideline for diagnostic flexible bronchoscopy in adults: accredited by nice, Thorax, vol.68, pp.1-44, 2013. ,
Under-and over-diagnosis of COPD: a global perspective, Breathe (Sheff), vol.15, pp.346-2018, 2019. ,
Cystic fibrosis airway epithelium remodelling: involvement of inflammation, J Pathol, vol.235, pp.408-427, 2015. ,
Air-liquid interface culture of human and mouse airway epithelial cells, Methods Mol Biol, vol.1809, pp.91-109, 2018. ,
Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface, Sci Rep, vol.5, p.8163, 2015. ,
Culturing of human nasal epithelial cells at the air liquid interface, J Vis Exp, 2013. ,
The airliquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia, Am J Physiol Lung Cell Mol Physiol, vol.300, pp.25-31, 2011. ,
Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures, Development, 2019. ,
Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site, J Biol Chem, vol.285, pp.26570-80, 2010. ,
Two critical periods of sonic hedgehog signaling required for the specification of motor neuron identity, Cell, vol.87, pp.661-73, 1996. ,
Regular articles: conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration, J Invest Dermatol, vol.114, pp.901-909, 2000. ,
Mapping sonic hedgehog-receptor interactions by steric interference, J Biol Chem, vol.275, pp.10995-1001, 2000. ,
Identification of a palmitic acid-modified form of human sonic hedgehog, J Biol Chem, vol.273, pp.14037-14082, 1998. ,
Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts, Br J Cancer, vol.116, pp.50-57, 2017. ,
Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach, PLoS One, vol.8, p.75225, 2013. ,
Ptch2 mediates the Shh response in Ptch1-/-cells, Development, vol.141, pp.3331-3340, 2014. ,
Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions, Am J Physiol Gastrointest Liver Physiol, vol.299, pp.1252-65, 2010. ,
Sonic hedgehog promotes desmoplasia in pancreatic cancer, Clin Cancer Res, vol.14, pp.5995-6004, 2008. ,
Sonic hedgehog signalling in neurons of adult ventrolateral nucleus tractus solitarius, Eur J Neurosci, vol.22, pp.389-96, 2005. ,
URL : https://hal.archives-ouvertes.fr/hal-00018205
Alteration of primary cilia in COPD, Eur Respir J, vol.52, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-02431953
Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals, Int J Oncol, vol.35, pp.187-92, 2009. ,
The "one airway, one disease" concept in light of Th2 inflammation, Eur Respir J, vol.52, 2018. ,
The hedgehog system machinery controls transforming growth factor-b-dependent myofibroblastic differentiation in humans: involvement in idiopathic pulmonary fibrosis, Am J Pathol, vol.181, pp.2126-2163, 2012. ,
The Hedgehog target GLI1 is not required for bleomycin-induced lung fibrosis, Exp Lung Res, vol.45, pp.22-31, 2019. ,
Targeting the sonic hedgehog signaling pathway: review of smoothened and GLI inhibitors, Cancers (Basel), vol.8, 2016. ,
Airway mucin concentration as a marker of chronic bronchitis, N Engl J Med, vol.377, pp.911-933, 2017. ,
Mucins, mucus, and goblet cells, Chest, vol.154, pp.169-76, 2018. ,
Gel-forming mucins form distinct morphologic structures in airways, Proc Natl Acad Sci, vol.114, pp.6842-6849, 2017. ,
Hedgehog signaling: from basic biology to cancer therapy, Cell Chem Biol, vol.24, pp.252-80, 2017. ,
Transcriptional regulation of graded Hedgehog signaling, Semin Cell Dev Biol, vol.33, pp.73-80, 2014. ,
Gli proteins: regulation in development and cancer, Cells, vol.8, 2019. ,
The human lung cell atlas: a high-resolution reference map of the human lung in health and disease, Am J Respir Cell Mol Biol, vol.61, pp.31-41, 2019. ,
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis, Am J Respir Crit Care Med, vol.199, pp.1517-1553, 2019. ,
Allergic inflammatory memory in human respiratory epithelial progenitor cells, Nature, vol.560, pp.649-54, 2018. ,
Next-generation Hedgehog/GLI pathway inhibitors for cancer therapy, Cancers (Basel), vol.11, 2019. ,
Recent advances in the clinical targeting of Hedgehog/GLI signaling in cancer, Cells, vol.8, 2019. ,
Targeting the Hedgehog pathway in cancer: current evidence and future perspectives, Cells, vol.8, 2019. ,
Targeting Hedgehog signaling pathway: paving the road for cancer therapy, Pharmacol Res, vol.141, pp.466-80, 2019. ,
Role of GLI transcription factors in pathogenesis and their potential as new therapeutic targets, Int J Mol Sci, vol.19, 2018. ,
Cilia and mucociliary clearance, Cold Spring Harb Perspect Biol, vol.9, p.28241, 2017. ,
Airway epithelial differentiation and mucociliary clearance, Ann Am Thorac Soc, vol.15, pp.143-151, 2018. ,
An introduction to the performance of immunohistochemistry, Methods Mol Biol, vol.1897, pp.289-98, 2019. ,
Lung histological methods, Methods Mol Biol, vol.1809, pp.315-344, 2018. ,
Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway, Oncol Lett, vol.15, pp.6077-86, 2018. ,
Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning, Development, vol.140, pp.3423-3457, 2013. ,
Whole-Genome sequencing in severe chronic obstructive pulmonary disease, Am J Respir Cell Mol Biol, vol.59, pp.614-636, 2018. ,
Metabolomic profiling in a hedgehog interacting protein (Hhip) murine model of chronic obstructive pulmonary disease, Sci Rep, vol.7, p.2504, 2017. ,
A Shh coreceptor Cdo is required for efficient cardiomyogenesis of pluripotent stem cells, J Mol Cell Cardiol, vol.93, pp.57-66, 2016. ,
Gas1 is a receptor for sonic hedgehog to repel enteric axons, Proc Natl Acad Sci, vol.112, pp.73-80, 2015. ,
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation, Dev Cell, vol.20, pp.788-801, 2011. ,
Gene editing and genetic lung disease. basic research meets therapeutic application, Am J Respir Cell Mol Biol, vol.56, pp.283-90, 2017. ,
The use of CRISPR-Cas9 technology to reveal important aspects of human airway biology, Methods Mol Biol, vol.1799, pp.371-80, 2018. ,
Animal and model systems for studying cystic fibrosis, J Cyst Fibros, vol.17, pp.28-34, 2018. ,
Brushed nasal epithelial cells are a surrogate for bronchial epithelial CFTR studies, JCI Insight, vol.3, 2018. ,
Airway basal cells. The "smoking gun" of chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.190, pp.1355-62, 2014. ,