HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Inactivation of the interleukin-22 pathway in the airways of cystic fibrosis patients

Abstract : Interleukin (IL)-22 plays a critical role in regulating the maintenance of the mucosal barrier. As airway epithelial regeneration is abnormal in cystic fibrosis (CF), we investigated IL-22 integrity in CF. We first demonstrated, using Il-22-/- mice, that IL-22 is important to prevent lung damage induced by the CF pathogen Pseudomonas aeruginosa. Next, IL-22 receptor was found normally expressed at the airway epithelial surfaces of CF patients. In wound-healing assays, IL-22-treated CF cultures had higher wound-closure rate than controls, suggesting that IL-22 signaling per se could be functional in a CF context. However, persistence of neutrophil-derived serine-proteases is a major feature of CF airways. Remarkably, IL-22 was found altered in this protease-rich inflammatory microenvironment; the serine protease-3 being the most prone to fully degrade IL-22. Consequently, we suspect an acquired deficiency of the IL-22 pathway in the lungs of CF patients due to IL-22 cleavage by the surrounding neutrophil serine-proteases.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-reims.fr/hal-02448633
Contributor : Valerian Dormoy Connect in order to contact the contributor
Submitted on : Thursday, July 2, 2020 - 3:05:24 PM
Last modification on : Tuesday, May 17, 2022 - 10:58:31 AM

Identifiers

Citation

Antoine Guillon, Deborah Brea, Emilie Luczka, Virginie Herve, Soujoud Hasanat, et al.. Inactivation of the interleukin-22 pathway in the airways of cystic fibrosis patients. Cytokine, Elsevier, 2019, 113 (1), pp.470-474. ⟨10.1016/j.cyto.2018.10.015⟩. ⟨hal-02448633⟩

Share

Metrics

Record views

101

Files downloads

121