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Plasticité phénotypique et thérapies ciblées dans les cancers bronchiques non à petites cellules

Abstract : Lung cancer is the most diagnosed and deathly type of cancer worldwide. It has a poor prognosis because of a late diagnosis, high metastatic potential and resistance to conventional therapies. Since the 2000s, the emergence of targeted therapies has improved patients' outcomes. However, these therapies concern only a small proportion of patients, selected by the presence of molecular biomarkers that indicate the targeting relevance. Here, we discuss the possibility that new phenotypical biomarkers could be predictive factors for targeted therapies in lung cancer.
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Jordan da Silva, Véronique Dalstein, Myriam Polette, Béatrice Nawrocki-Raby. Plasticité phénotypique et thérapies ciblées dans les cancers bronchiques non à petites cellules. Revue des Maladies Respiratoires, Elsevier Masson, 2019, 36 (4), pp.438-441. ⟨10.1016/j.rmr.2019.03.004⟩. ⟨hal-02448654⟩

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