Relationship between gender and survival in a real-life cohort of patients with COPD
Résumé
Background: Although COPD affects both men and women, its prevalence is increasing more rapidly in women.
Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whether
this translates into a different prognosis remains to be determined. Our aim was to assess whether the greater clinical
impact of COPD in women was associated with differences in 3-year mortality rates.
Methods: In the French Initiatives BPCO real-world cohort, 177 women were matched up to 458 menon age (within 5-
year intervals) and FEV1 (within 5% predicted intervals). 3-year mortality rate and survival were analyzed. Univariate and
multivariate logistic regression analyses were performed.
Results: For a given age and level of airflow obstruction, women with COPD had more severe dyspnea, lower BMI, and
were more likely to exhibit anxiety. Nevertheless, three-year mortality rate was comparable among men and women,
respectively 11.2 and 10.8%. In a multivariate model, the only factors significantly associated with mortality were dyspnea
and malnutrition but not gender.
Conclusion: Although women with COPD experience higher levels of dyspnea and anxiety than men at comparable
levels of age and FEV1, these differences do not translate into variations in 3-year mortality rates.
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