Human papillomavirus molecular biology and disease association, Rev Med Virol, vol.25, issue.1, pp.2-23, 2015. ,
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53, Cell, vol.63, pp.1129-1136, 1990. ,
Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products, Cancer Surv, vol.12, pp.197-217, 1992. ,
Human papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor, J Virol, vol.81, pp.9737-9747, 2007. ,
Human papillomaviruses in the pathogenesis of anogenital cancer, Virology, vol.184, pp.9-13, 1991. ,
Methylation of human papillomavirus Type 16 CpG sites at E2-binding site 1 (E2BS1), E2BS2, and the Sp1-binding site in cervical cancer samples as determined by high-resolution melting analysis-PCR, J Clin Microbiol, vol.51, pp.3207-3215, 2013. ,
Effects of methylation status of CpG sites within the HPV16 long control region on HPV16-positive head and neck cancer cells, PLoS One, vol.10, p.141245, 2015. ,
-aza-2'-deoxycytidine (DAC) treatment downregulates the HPV E6 and E7 oncogene expression and blocks neoplastic growth of HPV-associated cancer cells, Oncotarget, vol.8, issue.5, pp.52104-52117, 2016. ,
5azadC treatment upregulates miR-375 level and represses HPV16 E6 expression, Oncotarget, vol.8, pp.46163-46176, 2017. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01971566
activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3?, Mol Cancer, vol.13, p.80, 2014. ,
The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs, J Virol, vol.87, pp.4461-4474, 2013. ,
T-box transcription factors in cancer biology, Biochim Biophys Acta, vol.1846, pp.380-391, 2014. ,
The T-box transcription factor Tbx2: Its role in development and possible implication in cancer, IUBMB Life, vol.62, pp.92-102, 2010. ,
Effect of silencing the T-Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells, Mol Med Rep, vol.16, pp.6050-6058, 2017. ,
Transcriptomic alterations in lung adenocarcinoma unveil new mechanisms targeted by the TBX2 subfamily of tumor suppressor genes, Front Oncol, vol.8, p.482, 2018. ,
TBX2 subfamily suppression in lung cancer pathogenesis: A high-potential marker for early detection, Oncotarget, vol.8, pp.68230-68241, 2017. ,
Genome-wide DNA methylation profiling integrated with gene expression profiling identifiesPAX9as a novel prognostic marker in chronic lymphocytic leukemia, Clin Epigenetics, vol.9, p.57, 2017. ,
Epigenetic changes as prognostic predictors in endometrial carcinomas, Epigenetics, vol.12, pp.19-26, 2017. ,
Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers, Eur Urol, vol.61, pp.1245-1256, 2012. ,
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method, Methods, vol.25, pp.402-408, 2001. ,
Myelodysplastic syndromes: Contemporary review and how we treat, Am J Hematol, vol.91, pp.76-89, 2016. ,
The european medicines agency review of decitabine (Dacogen) for the treatment of adult patients with acute myeloid leukemia: Summary of the scientific assessment of the committee for medicinal products for human use, Oncologist, vol.21, pp.692-700, 2016. ,
Demethylation therapy as a targeted treatment for human papillomavirus-associated head and neck cancer, Clin Cancer Res, vol.23, pp.7276-7287, 2017. ,
Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor, Cancer Res, vol.64, pp.1669-1674, 2004. ,
, Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers, vol.26, pp.291-299, 2000.
Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas, Cancer Res, vol.65, pp.2260-2268, 2005. ,
Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development, Development, vol.131, pp.5041-5052, 2004. ,
URL : https://hal.archives-ouvertes.fr/hal-00311141
Tbx2 and Tbx3 act downstream of shh to maintain canonical wnt signaling during branching morphogenesis of the murine lung, Dev Cell, vol.39, pp.239-253, 2016. ,
, TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle, vol.35, pp.4212-4224, 2016.
T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells, Oncogene, vol.29, pp.3252-3262, 2010. ,