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Journal Articles Head & Neck Year : 2019

Head and neck cancer during pregnancy


Background:The incidence of cancer during pregnancy is low but is slightly increas-ing. Data on incidence and etiology of head and neck (HN) cancers in pregnantwomen are rare. We evaluated the frequency, tumor type, associated factors, and spe-cific biomarkers in HN cancers occurring in pregnant (and peripartum) women.Methods:A systematic literature search was performed on PubMed, for any HNtumor site occurring in pregnant women.Results:Sixty cases of HN cancers occurring during pregnancy were identified.Most of them were oral cavity cancers. Relationships with oncogenic viruses, hor-monal disturbance, and shift in maternal immunity profile were identified.Conclusion:Carcinogenesis of HN cancers in pregnant women may be led by dif-ferent cancer type–specific hallmarks. Relevance of these etiological factors withrespect to treatments and birth control recommendations is being investigated bythe REFCOR in an ambispective study.
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hal-02453751 , version 1 (24-01-2020)



Jennifer Le Guévelou, Sabrina Lebars, Emmanuel Kammerer, Ludovic Gabory, Sebastien Vergez, et al.. Head and neck cancer during pregnancy. Head & Neck, 2019, 41 (10), pp.3719-3732. ⟨10.1002/hed.25877⟩. ⟨hal-02453751⟩
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