The analysis by proton-decoupled carbon-13 nuclear magnetic resonance spectroscopy of samples dissolved in solvents presenting strong multiple resonances can be facilitated by the suppression of these resonances by multi-site presatu-ration. The advantage drawn from this operation is the elimination of the possible artifacts that arise from the solvent signals in non-optimized decoupling conditions. Solvent presaturation was implemented on glycerol, 1,2-propanediol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol with at least 94 % on-resonance efficiency and a bandwidth of less than 50 Hz measured at 5 50 % signal intensity decrease. The experimental measurement of the signal suppression bandwidth leads to unexpected se-lectivity profiles for frequency close resonances. Computer resolution of the Bloch equations during multi-site presaturation provide an insight into the origin of the observed profile perturbations.