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A new 2-alkylhydroquinone glucoside from Phagnalon saxatile (L.) Cass

Hanene Cherchar 1 Meriem Lehbili 1 Djemaa Berrehal 1 Hamid Morjani 2 Abdulmagid Alabdul Magid 3 Laurence Voutquenne-Nazabadioko 3 Ahmed Kabouche 1 Zahia Kabouche 1
1 UMC - Université Mentouri Constantine [Algérie]
2 MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369
3 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
Abstract : A new 2-alkylhydroquinone glucoside, 1-O-β-d-glucopyranosyl-1,4-dihydroxy-2-((E) 2-oxo-3-butenyl)benzene (1), in addition to nine known compounds were isolated from the aerial parts of Phagnalon saxatile (L.) Cass. (Asteraceae). Their structures were identified based on spectroscopic methods including 1D and 2D NMR, mass spectrometry (HR-ESI-MS), UV spectral analyses and by comparison with literature data. The cytotoxic activity of three isolated compounds (1-3) was evaluated against fibrosarcoma (HT1080), human lung cancer (A549) and breast cancer (MCF7) cell lines.
Keywords : cytotoxic activity alkylhydroquinone glucoside Phagnalon saxatile (L.) Cass Asteraceae
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https://hal.univ-reims.fr/hal-02929189
Contributor : Brigitte Perron <>
Submitted on : Thursday, September 3, 2020 - 11:34:39 AM
Last modification on : Wednesday, June 2, 2021 - 11:58:14 AM

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URCA | ICMR | MEDYC | INC-CNRS | CNRS | CAPSANTE

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Hanene Cherchar, Meriem Lehbili, Djemaa Berrehal, Hamid Morjani, Abdulmagid Alabdul Magid, et al.. A new 2-alkylhydroquinone glucoside from Phagnalon saxatile (L.) Cass. Natural Product Research, Taylor & Francis, 2018, 32 (9), pp.1010-1016. ⟨10.1080/14786419.2017.1375918⟩. ⟨hal-02929189⟩

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