Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert - Archive ouverte HAL Access content directly
Journal Articles Phytochemistry Letters Year : 2020

Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert

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Abstract

Five previously undescribed compounds, megalocarpoidolide I (1), megalocarpoidolide J (3), 12-epi-crotonzambefuran A (4), megalocarpoidolide K (5), 1-trans-p-hydroxycoumaroyl-geranylgerani-1-ol (6) were isolated from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. The known ent-trachyloban-18-ol, megalocarpoidolide B, megalocarpoidolide C (2), megalocarpoidolide H, crotocorylifuran, 7,8-dehydrocrotocorylifuran, 1,2-dehydrocrotocorylifuran-2-one, acetyl aleuritolic acid, lupeol, N-trans-p-coumaroyl-3',4'-dihydroxyphenylethylamine, dodecyl trans-ferulate and lignoceryl trans-ferulate were also isolated. The structures of the compounds were determined using NMR and IR spectroscopy and HRMS. The structure of compound 1 was determined using Logic for Structural Determination (LSD). Compounds 1, 2 and 3 were evaluated against the NCI60 panel of human tumour cell lines at 10µM level but found to be inactive.
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Dates and versions

hal-02934856 , version 1 (01-10-2020)

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Moses Langat, Beth Ndunda, Caitlin Salter, Babatope Odusina, Sani Isyaka, et al.. Diterpenoids from the stem bark of Croton megalocarpoides Friis & M. G. Gilbert. Phytochemistry Letters, 2020, 39, pp.1-7. ⟨10.1016/j.phytol.2020.07.003⟩. ⟨hal-02934856⟩
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