Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression - Archive ouverte HAL Access content directly
Journal Articles Frontiers in Oncology Year : 2020

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

(1) , (1) , (1) , (1, 2) , (1, 2) , (1)
1
2

Abstract

The tumor microenvironment (TME) is composed of various cell types embedded in an altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also regulates cell-cell or cell-matrix cross-talks. Alterations in ECM may be induced by hypoxia and acidosis, by oxygen free radicals generated by infiltrating inflammatory cells or by tumor-or stromal cell-secreted proteases. A poorer diagnosis for patients is often associated with ECM alterations. Tumor ECM proteome, also named cancer matrisome, is strongly altered, and different ECM protein signatures may be defined to serve as prognostic biomarkers. Collagen network reorganization facilitates tumor cell invasion. Proteoglycan expression and location are modified in the TME and affect cell invasion and metastatic dissemination. ECM macromolecule degradation by proteases may induce the release of angiogenic growth factors but also the release of proteoglycan-derived or ECM protein fragments, named matrikines or matricryptins. This review will focus on current knowledge and new insights in ECM alterations, degradation, and reticulation through cross-linking enzymes and on the role of ECM fragments in the control of cancer progression and their potential use as biomarkers in cancer diagnosis and prognosis.
Fichier principal
Vignette du fichier
Brassart Pasco et al fonc-10-00397 2020.pdf (543.95 Ko) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

hal-02986559 , version 1 (17-11-2020)

Identifiers

Cite

Sylvie Brassart-Pasco, Stéphane Brézillon, Bertrand Brassart, Laurent Ramont, Jean-Baptiste Oudart, et al.. Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression. Frontiers in Oncology, 2020, 10, ⟨10.3389/fonc.2020.00397⟩. ⟨hal-02986559⟩
99 View
61 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More