 |
Journal articles
EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis
Abstract : Epithelial-mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. Accordingly, EMTs play a crucial role in the biology of circulating tumor cells (CTCs) and contribute to their heterogeneity. Here, we review major EMT-driven properties that may help hybrid Epithelial/Mesenchymal CTCs to survive in the bloodstream and accomplish early phases of metastatic colonization. We then discuss how interrogating EMT in CTCs as a companion biomarker could help refine cancer patient management, further supporting the relevance of CTCs in personalized medicine.
https://hal.univ-reims.fr/hal-03038151
Contributor : Valerian Dormoy <>
Submitted on : Thursday, December 3, 2020 - 12:32:03 PM
Last modification on : Friday, December 18, 2020 - 1:41:29 PM
Contributor : Valerian Dormoy <>
Submitted on : Thursday, December 3, 2020 - 12:32:03 PM
Last modification on : Friday, December 18, 2020 - 1:41:29 PM
File
AnthonyGenna_Cancers_2020.pdf
Publisher files allowed on an open archive