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EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis

Abstract : Epithelial-mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. Accordingly, EMTs play a crucial role in the biology of circulating tumor cells (CTCs) and contribute to their heterogeneity. Here, we review major EMT-driven properties that may help hybrid Epithelial/Mesenchymal CTCs to survive in the bloodstream and accomplish early phases of metastatic colonization. We then discuss how interrogating EMT in CTCs as a companion biomarker could help refine cancer patient management, further supporting the relevance of CTCs in personalized medicine.
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https://hal.univ-reims.fr/hal-03038151
Contributor : Valerian Dormoy <>
Submitted on : Thursday, December 3, 2020 - 12:32:03 PM
Last modification on : Monday, May 17, 2021 - 2:52:24 PM
Long-term archiving on: : Thursday, March 4, 2021 - 7:04:52 PM

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Anthony Genna, Aline Vanwynsberghe, Amélie Villard, Charles Pottier, Julien Ancel, et al.. EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis. Cancers, MDPI, 2020, 12 (6), pp.1632. ⟨10.3390/cancers12061632⟩. ⟨hal-03038151⟩

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