EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis - Archive ouverte HAL Access content directly
Journal Articles Cancers Year : 2020

EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis

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Abstract

Epithelial-mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced ability to adapt to diverse microenvironments encountered during the metastatic spread. Accordingly, EMTs play a crucial role in the biology of circulating tumor cells (CTCs) and contribute to their heterogeneity. Here, we review major EMT-driven properties that may help hybrid Epithelial/Mesenchymal CTCs to survive in the bloodstream and accomplish early phases of metastatic colonization. We then discuss how interrogating EMT in CTCs as a companion biomarker could help refine cancer patient management, further supporting the relevance of CTCs in personalized medicine.
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hal-03038151 , version 1 (03-12-2020)

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Anthony Genna, Aline Vanwynsberghe, Amélie Villard, Charles Pottier, Julien Ancel, et al.. EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis. Cancers, 2020, 12 (6), pp.1632. ⟨10.3390/cancers12061632⟩. ⟨hal-03038151⟩
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