Prolonged mountain biking can involve pain complain in the wrists due to the ulnar nerve compression when using traditional grips (Capitani et al., 2002; Eckman et al., 1975). This phenomenon seems to be amplified by mechanical vibrations that are largely encountered during MTB practice despite the use of damping systems located in the fork and/or the frame. Recently, SPIRGRIPS® (SG) have been designed to correct the position of the hands of the user naturally by aligning the joints of his forearms correctly which is not the case with traditional grips. The aim of this experimental study was to evaluate the effect of SG on transmissibility of mechanical vibrations, perceived comfort, muscular activity and hand grip force during a prolonged pedalling exercise.