Incidence of diabetes in HIV-infected patients treated with first-line integrase strand transfer inhibitors: a French multicentre retrospective study
Axel Ursenbach
,
Vincent Max
,
Marine Maurel
,
C Drobacheff-Thiébaut
,
A Foltzer
,
K Bouiller
,
L Hustache-Mathieu
,
C Chirouze
,
Q Lepiller
,
F Bozon
,
O Babre
,
A Brunel
,
P Muret
,
H Laurichesse
,
O Lesens
,
M Vidal
,
N Mrozek
,
C Aumeran
,
O Baud
,
V Corbin
,
P Letertre-Gibert
,
S Casanova
,
J Prouteau
,
C Jacomet
,
I Lamaury
,
I Fabre
,
E Curlier
,
R Ouissa
,
C Herrmann-Storck
,
B Tressieres
,
T Bonijoly
,
M Receveur
,
F Boulard
,
C Daniel
,
C Clavel
,
D Merrien
,
P Perré
,
T Guimard
,
O Bollangier
,
S Leautez
,
M Morrier
,
L Laine
,
F Ader
,
A Becker
,
F Biron
,
A Boibieux
,
L Cotte
,
T Ferry
,
P Miailhes
,
T Perpoint
,
Stéphane Roux
,
C Triffault-Fillit
,
S Degroodt
,
C Brochier
,
F Valour
,
C Chidiac
,
A Ménard
,
A Belkhir
,
P Colson
,
C Dhiver
,
A Madrid
,
M Martin-Degiovani
,
L Meddeb
,
M Mokhtari
,
A Motte
,
A Raoux
,
Isabelle Ravaux
(1)
,
C Tamalet
,
C Toméi
,
H Tissot Dupont
,
S Brégigeon
,
O Zaegel-Faucher
,
V Obry-Roguet
,
H Laroche
,
M Orticoni
,
M Soavi
,
P Geneau de Lamarlière
,
E Ressiot
,
M Ducassou
,
I Jaquet
,
S Galie
,
A Galinier
,
P Martinet
,
M Landon
,
A Ritleng
,
A Ivanova
,
C Debreux
,
C Lions
,
I Poizot-Martin
,
S Abel
,
O Cabras
,
L Cuzin
,
K Guitteaud
,
M Illiaquer
,
S Pierre-François
,
L Osei
,
J Pasquier
,
K Rome
,
E Sidani
,
J Turmel
,
C Varache
,
A Cabié
,
N Atoui
,
M Bistoquet
,
E Delaporte
(2, 3)
,
V Le Moing
(2, 3)
,
Alain Makinson
(4, 3)
,
N Meftah
,
C Merle de Boever
,
B Montes
,
a Montoya Ferrer
,
E Tuaillon
(2, 5)
,
J Reynes
(2, 3)
,
M André
,
L Boyer
,
M Bouillon
,
M Delestan
,
C Rabaud
,
T May
,
B Hoen
,
C Allavena
,
C Bernaud
,
E Billaud
,
C Biron
,
B Bonnet
,
S Bouchez
,
D Boutoille
,
C Brunet-Cartier
,
C Deschanvres
,
N Hall
,
P Morineau
,
V Reliquet
,
S Sécher
,
M Cavellec
,
A Soria
,
V Ferré
,
E André-Garnier
,
A Rodallec
,
M Lefebvre
,
O Grossi
,
O Aubry
,
F Raffi
,
P Pugliese
,
S Breaud
,
C Ceppi
,
D Chirio
,
E Cua
,
P Dellamonica
,
E Demonchy
,
A de Monte
,
J Durant
,
C Etienne
,
S Ferrando
,
Rodolphe Garraffo
(6)
,
C Michelangeli
,
V Mondain
,
A Naqvi
,
N Oran
,
I Perbost
,
S Pillet
,
C Pradier
,
B Prouvost-Keller
,
K Risso
,
V Rio
,
P Roger
,
E Rosenthal
,
S Sausse
,
I Touitou
,
S Wehrlen-Pugliese
,
G Zouzou
,
L Hocqueloux
,
T Prazuck
,
C Gubavu
,
A Sève
,
A Maka
,
C Boulard
,
G Thomas
,
A Cheret
,
C Goujard
,
Y Quertainmont
,
E Teicher
,
N Lerolle
,
O Deradji
,
A Barrail-Tran
,
R Landman
,
V Joly
,
J Ghosn
,
C Rioux
,
S Lariven
,
A Gervais
,
F Lescure
,
S Matheron
,
F Louni
,
Z Julia
,
C Mackoumbou-Nkouka
,
S Le Gac
,
C Charpentier
,
D Descamps
,
G Peytavin
,
Y Yazdanpanah
,
K Amazzough
,
V Avettand-Fenoël
,
G Benabdelmoumen
,
P Bossi
,
G Cessot
,
C Charlier
,
P Consigny
,
F Danion
,
A Dureault
,
C Duvivier
,
J Goesch
,
R Guery
,
B Henry
,
K Jidar
,
F Lanternier
,
P Loubet
,
O Lortholary
,
C Louisin
,
J Lourenco
,
P Parize
,
B Pilmis
,
F Touam
,
M Valantin
,
R Tubiana
,
R Agher
,
S Seang
(7)
,
L Schneider
,
R Palich
,
C Blanc
,
C Katlama
,
J Berger
,
Y N’guyen
,
D Lambert
,
I Kmiec
,
M Hentzien
,
A Brunet
,
V Brodard
,
Firouzé Bani-Sadr
(8, 9)
,
P Tattevin
,
M Revest
,
F Souala
,
M Baldeyrou
,
S Patrat-Delon
,
J Chapplain
,
F Benezit
,
M Dupont
,
M Poinot
,
A Maillard
,
C Pronier
,
F Lemaitre
,
C Guennoun
,
M Poisson-Vanier
,
T Jovelin
,
J Sinteff
,
C Arvieux
,
E Botelho-Nevers
,
Amandine Gagneux-Brunon
(10)
,
A Frésard
,
V Ronat
,
F Lucht
,
P Fischer
,
M Partisani
,
C Cheneau
,
M Priester
,
M Batard
,
C Bernard-Henry
,
E de Mautort
,
S Fafi-Kremer
,
David Rey
(11)
,
M Alvarez
,
N Biezunski
,
A Debard
,
C Delpierre
,
P Lansalot
,
L Lelièvre
,
G Martin-Blondel
,
M Piffaut
,
L Porte
,
K Saune
,
P Delobel
,
F Ajana
,
E Aïssi
,
I Alcaraz
,
V Baclet
,
L Bocket
,
A Boucher
,
P Choisy
,
T Huleux
,
B Lafon-Desmurs
,
A Meybeck
,
M Pradier
,
Olivier Robineau
(12)
,
N Viget
,
M Valette
1
IHU Marseille -
Institut Hospitalier Universitaire Méditerranée Infection
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
3 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
4 Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France
5 Pathogénèse et contrôle des infections chroniques (PCCI)
6 Service de pharmacologie
7 THERAVIR - Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées [iPLesp]
8 CHU Reims - Centre Hospitalier Universitaire de Reims
9 CardioVir - Laboratoire de Virologie Médicale et Moléculaire - EA 4684
10 GIMAP - Groupe Immunité des Muqueuses et Agents Pathogènes
11 School of Civil and Environmental Engineering [Sydney]
12 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
2 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
3 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
4 Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France
5 Pathogénèse et contrôle des infections chroniques (PCCI)
6 Service de pharmacologie
7 THERAVIR - Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées [iPLesp]
8 CHU Reims - Centre Hospitalier Universitaire de Reims
9 CardioVir - Laboratoire de Virologie Médicale et Moléculaire - EA 4684
10 GIMAP - Groupe Immunité des Muqueuses et Agents Pathogènes
11 School of Civil and Environmental Engineering [Sydney]
12 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
Axel Ursenbach
- Function : Author
Vincent Max
- Function : Author
Marine Maurel
- Function : Author
C Drobacheff-Thiébaut
- Function : Author
A Foltzer
- Function : Author
K Bouiller
- Function : Author
L Hustache-Mathieu
- Function : Author
C Chirouze
- Function : Author
Q Lepiller
- Function : Author
F Bozon
- Function : Author
O Babre
- Function : Author
A Brunel
- Function : Author
P Muret
- Function : Author
H Laurichesse
- Function : Author
O Lesens
- Function : Author
M Vidal
- Function : Author
N Mrozek
- Function : Author
C Aumeran
- Function : Author
O Baud
- Function : Author
V Corbin
- Function : Author
P Letertre-Gibert
- Function : Author
S Casanova
- Function : Author
J Prouteau
- Function : Author
C Jacomet
- Function : Author
I Lamaury
- Function : Author
I Fabre
- Function : Author
E Curlier
- Function : Author
R Ouissa
- Function : Author
C Herrmann-Storck
- Function : Author
B Tressieres
- Function : Author
T Bonijoly
- Function : Author
M Receveur
- Function : Author
F Boulard
- Function : Author
C Daniel
- Function : Author
C Clavel
- Function : Author
D Merrien
- Function : Author
P Perré
- Function : Author
T Guimard
- Function : Author
O Bollangier
- Function : Author
S Leautez
- Function : Author
M Morrier
- Function : Author
L Laine
- Function : Author
F Ader
- Function : Author
A Becker
- Function : Author
F Biron
- Function : Author
A Boibieux
- Function : Author
L Cotte
- Function : Author
T Ferry
- Function : Author
P Miailhes
- Function : Author
T Perpoint
- Function : Author
Stéphane Roux
- Function : Author
C Triffault-Fillit
- Function : Author
S Degroodt
- Function : Author
C Brochier
- Function : Author
F Valour
- Function : Author
C Chidiac
- Function : Author
A Ménard
- Function : Author
A Belkhir
- Function : Author
P Colson
- Function : Author
C Dhiver
- Function : Author
A Madrid
- Function : Author
M Martin-Degiovani
- Function : Author
L Meddeb
- Function : Author
M Mokhtari
- Function : Author
A Motte
- Function : Author
A Raoux
- Function : Author
C Tamalet
- Function : Author
C Toméi
- Function : Author
H Tissot Dupont
- Function : Author
S Brégigeon
- Function : Author
O Zaegel-Faucher
- Function : Author
V Obry-Roguet
- Function : Author
H Laroche
- Function : Author
M Orticoni
- Function : Author
M Soavi
- Function : Author
P Geneau de Lamarlière
- Function : Author
E Ressiot
- Function : Author
M Ducassou
- Function : Author
I Jaquet
- Function : Author
S Galie
- Function : Author
A Galinier
- Function : Author
P Martinet
- Function : Author
M Landon
- Function : Author
A Ritleng
- Function : Author
A Ivanova
- Function : Author
C Debreux
- Function : Author
C Lions
- Function : Author
I Poizot-Martin
- Function : Author
S Abel
- Function : Author
O Cabras
- Function : Author
L Cuzin
- Function : Author
K Guitteaud
- Function : Author
M Illiaquer
- Function : Author
S Pierre-François
- Function : Author
L Osei
- Function : Author
J Pasquier
- Function : Author
K Rome
- Function : Author
E Sidani
- Function : Author
J Turmel
- Function : Author
C Varache
- Function : Author
A Cabié
- Function : Author
N Atoui
- Function : Author
M Bistoquet
- Function : Author
N Meftah
- Function : Author
C Merle de Boever
- Function : Author
B Montes
- Function : Author
a Montoya Ferrer
- Function : Author
M André
- Function : Author
L Boyer
- Function : Author
M Bouillon
- Function : Author
M Delestan
- Function : Author
C Rabaud
- Function : Author
T May
- Function : Author
B Hoen
- Function : Author
C Allavena
- Function : Author
C Bernaud
- Function : Author
E Billaud
- Function : Author
C Biron
- Function : Author
B Bonnet
- Function : Author
S Bouchez
- Function : Author
D Boutoille
- Function : Author
C Brunet-Cartier
- Function : Author
C Deschanvres
- Function : Author
N Hall
- Function : Author
P Morineau
- Function : Author
V Reliquet
- Function : Author
S Sécher
- Function : Author
M Cavellec
- Function : Author
A Soria
- Function : Author
V Ferré
- Function : Author
E André-Garnier
- Function : Author
A Rodallec
- Function : Author
M Lefebvre
- Function : Author
O Grossi
- Function : Author
O Aubry
- Function : Author
F Raffi
- Function : Author
P Pugliese
- Function : Author
S Breaud
- Function : Author
C Ceppi
- Function : Author
D Chirio
- Function : Author
E Cua
- Function : Author
P Dellamonica
- Function : Author
E Demonchy
- Function : Author
A de Monte
- Function : Author
J Durant
- Function : Author
C Etienne
- Function : Author
S Ferrando
- Function : Author
C Michelangeli
- Function : Author
V Mondain
- Function : Author
A Naqvi
- Function : Author
N Oran
- Function : Author
I Perbost
- Function : Author
S Pillet
- Function : Author
C Pradier
- Function : Author
B Prouvost-Keller
- Function : Author
K Risso
- Function : Author
V Rio
- Function : Author
P Roger
- Function : Author
E Rosenthal
- Function : Author
S Sausse
- Function : Author
I Touitou
- Function : Author
S Wehrlen-Pugliese
- Function : Author
G Zouzou
- Function : Author
L Hocqueloux
- Function : Author
T Prazuck
- Function : Author
C Gubavu
- Function : Author
A Sève
- Function : Author
A Maka
- Function : Author
C Boulard
- Function : Author
G Thomas
- Function : Author
A Cheret
- Function : Author
C Goujard
- Function : Author
Y Quertainmont
- Function : Author
E Teicher
- Function : Author
N Lerolle
- Function : Author
O Deradji
- Function : Author
A Barrail-Tran
- Function : Author
R Landman
- Function : Author
V Joly
- Function : Author
J Ghosn
- Function : Author
C Rioux
- Function : Author
S Lariven
- Function : Author
A Gervais
- Function : Author
F Lescure
- Function : Author
S Matheron
- Function : Author
F Louni
- Function : Author
Z Julia
- Function : Author
C Mackoumbou-Nkouka
- Function : Author
S Le Gac
- Function : Author
C Charpentier
- Function : Author
D Descamps
- Function : Author
G Peytavin
- Function : Author
Y Yazdanpanah
- Function : Author
K Amazzough
- Function : Author
V Avettand-Fenoël
- Function : Author
G Benabdelmoumen
- Function : Author
P Bossi
- Function : Author
G Cessot
- Function : Author
C Charlier
- Function : Author
P Consigny
- Function : Author
F Danion
- Function : Author
A Dureault
- Function : Author
C Duvivier
- Function : Author
J Goesch
- Function : Author
R Guery
- Function : Author
B Henry
- Function : Author
K Jidar
- Function : Author
F Lanternier
- Function : Author
P Loubet
- Function : Author
O Lortholary
- Function : Author
C Louisin
- Function : Author
J Lourenco
- Function : Author
P Parize
- Function : Author
B Pilmis
- Function : Author
F Touam
- Function : Author
M Valantin
- Function : Author
R Tubiana
- Function : Author
R Agher
- Function : Author
S Seang
- Function : Author
- PersonId : 1213628
- IdHAL : sophie-seang
- ORCID : 0000-0001-7724-9312
L Schneider
- Function : Author
R Palich
- Function : Author
C Blanc
- Function : Author
C Katlama
- Function : Author
J Berger
- Function : Author
Y N’guyen
- Function : Author
D Lambert
- Function : Author
I Kmiec
- Function : Author
M Hentzien
- Function : Author
A Brunet
- Function : Author
V Brodard
- Function : Author
Firouzé Bani-Sadr
- Function : Author
- PersonId : 770044
- ORCID : 0000-0001-8268-866X
- IdRef : 120562642
P Tattevin
- Function : Author
M Revest
- Function : Author
F Souala
- Function : Author
M Baldeyrou
- Function : Author
S Patrat-Delon
- Function : Author
J Chapplain
- Function : Author
F Benezit
- Function : Author
M Dupont
- Function : Author
M Poinot
- Function : Author
A Maillard
- Function : Author
C Pronier
- Function : Author
F Lemaitre
- Function : Author
C Guennoun
- Function : Author
M Poisson-Vanier
- Function : Author
T Jovelin
- Function : Author
J Sinteff
- Function : Author
C Arvieux
- Function : Author
E Botelho-Nevers
- Function : Author
A Frésard
- Function : Author
V Ronat
- Function : Author
F Lucht
- Function : Author
P Fischer
- Function : Author
M Partisani
- Function : Author
C Cheneau
- Function : Author
M Priester
- Function : Author
M Batard
- Function : Author
C Bernard-Henry
- Function : Author
E de Mautort
- Function : Author
S Fafi-Kremer
- Function : Author
M Alvarez
- Function : Author
N Biezunski
- Function : Author
A Debard
- Function : Author
C Delpierre
- Function : Author
P Lansalot
- Function : Author
L Lelièvre
- Function : Author
G Martin-Blondel
- Function : Author
M Piffaut
- Function : Author
L Porte
- Function : Author
K Saune
- Function : Author
P Delobel
- Function : Author
- PersonId : 900559
- ORCID : 0000-0002-2874-3581
F Ajana
- Function : Author
E Aïssi
- Function : Author
I Alcaraz
- Function : Author
V Baclet
- Function : Author
L Bocket
- Function : Author
A Boucher
- Function : Author
P Choisy
- Function : Author
T Huleux
- Function : Author
B Lafon-Desmurs
- Function : Author
A Meybeck
- Function : Author
M Pradier
- Function : Author
N Viget
- Function : Author
M Valette
- Function : Author
Abstract
Abstract Background Integrase strand transfer inhibitors (INSTIs) are increasingly used in patients living with HIV due to their safety, effectiveness and high genetic barrier. However, an association with weight gain has recently been suggested and several cases of diabetes mellitus have been reported with raltegravir and dolutegravir. The long-time metabolic impact of these recent molecules remains unclear. Objectives To assess if an INSTI as a third agent is statistically associated with new-onset diabetes mellitus compared with an NNRTI or a PI. Patients and methods Patients undergoing first-line combined ART (cART) without diabetes at baseline were retrospectively included from the Dat’AIDS French cohort study (ClinicalTrials.gov NCT02898987). Incident diabetes mellitus was defined as a notification of new diabetes in the medical history, a glycated haemoglobin (HbA1c) level superior to 7.5% or the start of a diabetes therapy following the initiation of ART. Results From 2009 to 2017, 19 462 patients were included, among which 265 cases of diabetes mellitus occurred. Multivariate and survival analyses did not highlight an increase in new-onset diabetes in patients undergoing cART with an INSTI as a third agent compared with an NNRTI or a PI. BMI >30 kg/m2, age >37 years old (in survival analysis), black race or Hispanic ethnicity, arterial hypertension and AIDS were associated with a higher proportion of incident diabetes. Conclusions INSTIs were not statistically associated with new-onset diabetes. However, clinicians should remain aware of this possible metabolic comorbidity, particularly in patients with a high BMI and older patients.