Reaching the Second and Third Joint United Nations Programme on Human Immunodeficiency Virus (HIV)/AIDS 90-90-90 Targets Is Accompanied by a Dramatic Reduction in Primary HIV Infection and in Recent HIV Infections in a Large French Nationwide HIV Cohort
Adrien Le Guillou
,
Moustapha Drame
(1)
,
M Orticoni
,
M Soavi
,
I Luquet- Besson
,
E Ressiot
,
M Carta- Padovani
,
M Ducassou
,
H Bertone
,
S Galie
,
A Galinier
,
M Monclar
,
A Ritleng
,
A Ivanova
,
C Blanco-Betancourt
,
C Lions
,
I Poizot-Martin
,
C Dhiver
,
M Saadia Mokhtari
,
A Ménard
,
H Tissot Dupont
,
C Toméi
,
L Meddeb
,
A Belkhir
,
I Ravaux
,
M Alvarez
,
N Biezunski
,
A Debard
,
C Delpierre
,
P Lansalot
,
L Lelièvre
,
G Martin-Blondel
,
M Piffaut
,
L Porte
,
K Saune
,
P Delobel
,
Pascal Pugliese
(2)
,
S Breaud
,
C Ceppi
,
D Chirio
,
E Cua
,
P Dellamonica
,
E Demonchy
,
A de Monte
,
J Durant
,
C Etienne
,
S Ferrando
,
R Garraffo
,
C Michelangeli
,
V Mondain
,
Clotilde Allavena
(3)
,
C Bernaud
,
E Billaud
,
C Biron
,
B Bonnet
,
S Bouchez
,
D Boutoille
,
C Brunet-Cartier
,
C Deschanvres
,
B Gaborit
,
N Hall
,
P Le Turnier
,
P Morineau
,
V Reliquet
,
S Sécher
,
M Cavellec
,
A Soria
,
V Ferré
,
E André-Garnier
,
A Rodallec
,
M Lefebvre
,
O Grossi
,
O Aubry
,
François Raffi
(4)
,
K Amazzough
,
G Benabdelmoumen
,
P Bossi
,
G Cessot
,
C Charlier
,
P Consigny
,
F Danion
,
A Dureault
,
C Duvivier
,
J Goesch
,
R Guery
,
B Henry
,
K Jidar
,
F Lanternier
,
P Loubet
,
O Lortholary
,
C Louisin
,
J Lourenco
,
P Parize
,
B Pilmis
,
F Touam
,
M Valantin
,
R Tubiana
,
R Agher
,
S Seang
,
L Schneider
,
R Palich
,
C Blanc
,
Christine Katlama
(5)
,
André Cabie
(1)
,
Lise Cuzin
(6)
,
S Abel
,
S Pierre-François
,
J Pasquier
,
K Guitteaud
,
J Turmel
,
M Illiaquer
,
P Fischer
,
M Partisani
,
C Cheneau
,
M Priester
,
M Batard
,
C Bernard-Henry
,
E de Mautort
,
S Fafi-Kremer
,
D Rey
,
C Chirouze
,
Q Gardiennet
,
Firouzé Bani-Sadr
(7, 8)
,
J Berger
,
Y N’guyen
,
D Lambert
,
M Hentzien
,
D Lebrun
,
A Brunet
,
I Kmiec
,
V Brodard
,
Laurent Cotte
(9)
,
C Chidiac
,
T Ferry
,
F Ader
,
F Biron
,
A Boibieux
,
P Miailhes
,
T Perpoint
,
I Schlienger
,
J Lippmann
,
E Braun
,
J Koffi
,
C Longuet
,
V Guéripel
,
C Augustin-Normand
,
C Brochier
,
S Degroodt
,
N Atoui
,
V Le Moing
,
A Makinson
,
N Meftah
,
C Merle de Boever
,
B Montes
,
A Montoya Ferrer
,
J Reynes
,
M André
,
L Boyer
,
M Bouillon
,
M Delestan
,
T May
,
L Hocqueloux
,
T Prazuck
,
C Gubavu
,
A Sève
,
A Maka
,
C Boulard
,
G Thomas
,
A Cheret
,
C Goujard
,
Y Quertainmont
,
E Teicher
,
N Lerolle
,
O Deradji
,
A Barrail-Tran
,
R Landman
,
V Joly
,
C Rioux
,
S Lariven
,
A Gervais
,
F Lescure
,
S Matheron
,
F Louni
,
C Godard
,
Z Julia
,
M Chansombat
,
D Rahli
,
C Mackoumbou-Nkouka
,
C Charpentier
,
D Descamps
,
G Peytavin
,
Y Yazdanpanah
,
P Tattevin
,
M Revest
,
F Souala
,
M Baldeyrou
,
S Patrat-Delon
,
J Chapplain
,
F Benezit
,
M Dupont
,
M Poinot
,
A Maillard
,
C Pronier
,
F Lemaitre
,
C Guennoun
,
M Poisson-Vanier
,
T Jovelin
,
J Sinteff
,
C Arvieux
,
E Botelho-Nevers
,
A Gagneux-Brunon
,
A Frésard
,
F Lucht
,
F Ajana
,
E Aïssi
,
I Alcaraz
,
V Baclet
,
L Bocket
,
A Boucher
,
P Choisy
,
T Huleux
,
B Lafon-Desmurs
,
A Meybeck
,
M Pradier
,
O Robineau
,
N Viget
,
M Valette
,
B Hoen
,
I Lamaury
,
I Fabre
,
E Curlier
,
R Ouissa
,
K Schepers
,
C Herrmann-Storck
,
N Dournon
,
D Merrien
,
P Perré
,
T Guimard
,
O Bollangier
,
S Leautez
,
M Morrier
1
CHU de la Martinique [Fort de France]
2 CHU Nice - Centre Hospitalier Universitaire de Nice
3 Service de maladies infectieuses et tropicales [Nantes]
4 Department of Infectious Diseases [Nantes]
5 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
6 Infectious Diseases and Tropical Medicine Unit [Fort-de-France, Martinique]
7 CHU Reims - Centre Hospitalier Universitaire de Reims
8 CardioVir - Laboratoire de Virologie Médicale et Moléculaire - EA 4684
9 Département de maladies infectieuses
2 CHU Nice - Centre Hospitalier Universitaire de Nice
3 Service de maladies infectieuses et tropicales [Nantes]
4 Department of Infectious Diseases [Nantes]
5 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
6 Infectious Diseases and Tropical Medicine Unit [Fort-de-France, Martinique]
7 CHU Reims - Centre Hospitalier Universitaire de Reims
8 CardioVir - Laboratoire de Virologie Médicale et Moléculaire - EA 4684
9 Département de maladies infectieuses
Adrien Le Guillou
- Function : Author
Moustapha Drame
- Function : Author
- PersonId : 1069417
- ORCID : 0000-0002-6662-8832
- IdRef : 136340547
M Orticoni
- Function : Author
M Soavi
- Function : Author
I Luquet- Besson
- Function : Author
E Ressiot
- Function : Author
M Carta- Padovani
- Function : Author
M Ducassou
- Function : Author
H Bertone
- Function : Author
S Galie
- Function : Author
A Galinier
- Function : Author
M Monclar
- Function : Author
A Ritleng
- Function : Author
A Ivanova
- Function : Author
C Blanco-Betancourt
- Function : Author
C Lions
- Function : Author
I Poizot-Martin
- Function : Author
C Dhiver
- Function : Author
M Saadia Mokhtari
- Function : Author
A Ménard
- Function : Author
H Tissot Dupont
- Function : Author
C Toméi
- Function : Author
L Meddeb
- Function : Author
A Belkhir
- Function : Author
I Ravaux
- Function : Author
M Alvarez
- Function : Author
N Biezunski
- Function : Author
A Debard
- Function : Author
C Delpierre
- Function : Author
P Lansalot
- Function : Author
L Lelièvre
- Function : Author
G Martin-Blondel
- Function : Author
M Piffaut
- Function : Author
L Porte
- Function : Author
K Saune
- Function : Author
P Delobel
- Function : Author
- PersonId : 900559
- ORCID : 0000-0002-2874-3581
S Breaud
- Function : Author
C Ceppi
- Function : Author
D Chirio
- Function : Author
E Cua
- Function : Author
P Dellamonica
- Function : Author
E Demonchy
- Function : Author
A de Monte
- Function : Author
J Durant
- Function : Author
C Etienne
- Function : Author
S Ferrando
- Function : Author
R Garraffo
- Function : Author
C Michelangeli
- Function : Author
V Mondain
- Function : Author
Clotilde Allavena
- Function : Author
- PersonId : 765804
- ORCID : 0000-0003-1010-1270
C Bernaud
- Function : Author
E Billaud
- Function : Author
C Biron
- Function : Author
B Bonnet
- Function : Author
S Bouchez
- Function : Author
D Boutoille
- Function : Author
C Brunet-Cartier
- Function : Author
C Deschanvres
- Function : Author
B Gaborit
- Function : Author
N Hall
- Function : Author
P Le Turnier
- Function : Author
P Morineau
- Function : Author
V Reliquet
- Function : Author
S Sécher
- Function : Author
M Cavellec
- Function : Author
A Soria
- Function : Author
V Ferré
- Function : Author
E André-Garnier
- Function : Author
A Rodallec
- Function : Author
M Lefebvre
- Function : Author
O Grossi
- Function : Author
O Aubry
- Function : Author
K Amazzough
- Function : Author
G Benabdelmoumen
- Function : Author
P Bossi
- Function : Author
G Cessot
- Function : Author
C Charlier
- Function : Author
P Consigny
- Function : Author
F Danion
- Function : Author
A Dureault
- Function : Author
C Duvivier
- Function : Author
J Goesch
- Function : Author
R Guery
- Function : Author
B Henry
- Function : Author
K Jidar
- Function : Author
F Lanternier
- Function : Author
P Loubet
- Function : Author
O Lortholary
- Function : Author
C Louisin
- Function : Author
J Lourenco
- Function : Author
P Parize
- Function : Author
B Pilmis
- Function : Author
F Touam
- Function : Author
M Valantin
- Function : Author
R Tubiana
- Function : Author
R Agher
- Function : Author
S Seang
- Function : Author
- PersonId : 1213628
- IdHAL : sophie-seang
- ORCID : 0000-0001-7724-9312
L Schneider
- Function : Author
R Palich
- Function : Author
C Blanc
- Function : Author
Lise Cuzin
- Function : Author
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S Abel
- Function : Author
S Pierre-François
- Function : Author
J Pasquier
- Function : Author
K Guitteaud
- Function : Author
J Turmel
- Function : Author
M Illiaquer
- Function : Author
P Fischer
- Function : Author
M Partisani
- Function : Author
C Cheneau
- Function : Author
M Priester
- Function : Author
M Batard
- Function : Author
C Bernard-Henry
- Function : Author
E de Mautort
- Function : Author
S Fafi-Kremer
- Function : Author
D Rey
- Function : Author
C Chirouze
- Function : Author
Q Gardiennet
- Function : Author
Firouzé Bani-Sadr
- Function : Author
- PersonId : 770044
- ORCID : 0000-0001-8268-866X
- IdRef : 120562642
J Berger
- Function : Author
Y N’guyen
- Function : Author
D Lambert
- Function : Author
M Hentzien
- Function : Author
D Lebrun
- Function : Author
A Brunet
- Function : Author
I Kmiec
- Function : Author
V Brodard
- Function : Author
C Chidiac
- Function : Author
T Ferry
- Function : Author
F Ader
- Function : Author
F Biron
- Function : Author
A Boibieux
- Function : Author
P Miailhes
- Function : Author
T Perpoint
- Function : Author
I Schlienger
- Function : Author
J Lippmann
- Function : Author
E Braun
- Function : Author
J Koffi
- Function : Author
C Longuet
- Function : Author
V Guéripel
- Function : Author
C Augustin-Normand
- Function : Author
C Brochier
- Function : Author
S Degroodt
- Function : Author
N Atoui
- Function : Author
V Le Moing
- Function : Author
A Makinson
- Function : Author
- PersonId : 778550
- ORCID : 0000-0003-2817-8444
N Meftah
- Function : Author
C Merle de Boever
- Function : Author
B Montes
- Function : Author
A Montoya Ferrer
- Function : Author
J Reynes
- Function : Author
M André
- Function : Author
L Boyer
- Function : Author
M Bouillon
- Function : Author
M Delestan
- Function : Author
T May
- Function : Author
L Hocqueloux
- Function : Author
T Prazuck
- Function : Author
C Gubavu
- Function : Author
A Sève
- Function : Author
A Maka
- Function : Author
C Boulard
- Function : Author
G Thomas
- Function : Author
A Cheret
- Function : Author
C Goujard
- Function : Author
Y Quertainmont
- Function : Author
E Teicher
- Function : Author
N Lerolle
- Function : Author
O Deradji
- Function : Author
A Barrail-Tran
- Function : Author
R Landman
- Function : Author
V Joly
- Function : Author
C Rioux
- Function : Author
S Lariven
- Function : Author
A Gervais
- Function : Author
F Lescure
- Function : Author
S Matheron
- Function : Author
F Louni
- Function : Author
C Godard
- Function : Author
Z Julia
- Function : Author
M Chansombat
- Function : Author
D Rahli
- Function : Author
C Mackoumbou-Nkouka
- Function : Author
C Charpentier
- Function : Author
D Descamps
- Function : Author
G Peytavin
- Function : Author
Y Yazdanpanah
- Function : Author
P Tattevin
- Function : Author
M Revest
- Function : Author
F Souala
- Function : Author
M Baldeyrou
- Function : Author
S Patrat-Delon
- Function : Author
J Chapplain
- Function : Author
F Benezit
- Function : Author
M Dupont
- Function : Author
M Poinot
- Function : Author
A Maillard
- Function : Author
C Pronier
- Function : Author
F Lemaitre
- Function : Author
C Guennoun
- Function : Author
M Poisson-Vanier
- Function : Author
T Jovelin
- Function : Author
J Sinteff
- Function : Author
C Arvieux
- Function : Author
E Botelho-Nevers
- Function : Author
A Gagneux-Brunon
- Function : Author
A Frésard
- Function : Author
F Lucht
- Function : Author
F Ajana
- Function : Author
E Aïssi
- Function : Author
I Alcaraz
- Function : Author
V Baclet
- Function : Author
L Bocket
- Function : Author
A Boucher
- Function : Author
P Choisy
- Function : Author
T Huleux
- Function : Author
B Lafon-Desmurs
- Function : Author
A Meybeck
- Function : Author
M Pradier
- Function : Author
O Robineau
- Function : Author
N Viget
- Function : Author
M Valette
- Function : Author
B Hoen
- Function : Author
I Lamaury
- Function : Author
I Fabre
- Function : Author
E Curlier
- Function : Author
R Ouissa
- Function : Author
K Schepers
- Function : Author
C Herrmann-Storck
- Function : Author
N Dournon
- Function : Author
D Merrien
- Function : Author
P Perré
- Function : Author
T Guimard
- Function : Author
O Bollangier
- Function : Author
S Leautez
- Function : Author
M Morrier
- Function : Author
Abstract
Abstract Background In late 2013, France was one of the first countries to recommend initiation of combination antiretroviral therapy (cART) irrespective of CD4 cell count. Methods To assess the impact of achieving the second and third Joint United Nations Programme on HIV/AIDS 90-90-90 targets (ie, 90% of diagnosed people on sustained cART, and, of those, 90% virologically controlled) on human immunodeficiency virus (HIV) incidence, we conducted a longitudinal study to describe the epidemiology of primary HIV infection (PHI) and/or recent HIV infection (patients with CD4 cell count ≥500/mm3 at HIV diagnosis; (PRHI) between 2007 and 2017 in a large French multicenter cohort. To identify changes in trends in PHI and PRHI, we used single breakpoint linear segmented regression analysis. Results During the study period, 61 822 patients were followed in the Dat’AIDS cohort; 2027 (10.0%) had PHI and 7314 (36.1%) had PRHI. The second and third targets were reached in 2014 and 2013, respectively. The median delay between HIV diagnosis and cART initiation decreased from 9.07 (interquartile range [IQR], 1.39–33.47) months in 2007 to 0.77 (IQR, 0.37–1.60) months in 2017. A decrease in PHI (−35.1%) and PRHI (−25.4%) was observed starting in 2013. The breakpoints for PHI and PRHI were 2012.6 (95% confidence interval [CI], 2010.8–2014.4) and 2013.1 (95% CI, 2011.3–2014.8), respectively. Conclusions Our findings show that the achievements of 2 public health targets in France and the early initiation of cART were accompanied by a reduction of about one-third in PHI and PRHI between 2013 and 2017. Clinical Trials Registration NCT02898987.