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Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia

Abstract : The gene cluster region, CHRNA3/CHRNA5/CHRNB4, encoding for nicotinic acetylcholine receptor (nAChR) subunits, contains several genetic variants linked to nicotine addiction and brain disorders. The CHRNA5 single-nucleotide polymorphism (SNP) rs16969968 is strongly associated with nicotine dependence and lung diseases. Using immunostaining studies on tissue sections and air-liquid interface airway epithelial cell cultures, in situ hybridisation, transcriptomic and cytokines detection, we analysed rs16969968 contribution to respiratory airway epithelial remodelling and modulation of inflammation. We provide cellular and molecular analyses which support the genetic association of this polymorphism with impaired ciliogenesis and the altered production of inflammatory mediators. This suggests its role in lung disease development.
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Contributor : Valerian Dormoy Connect in order to contact the contributor
Submitted on : Monday, July 5, 2021 - 1:20:17 PM
Last modification on : Thursday, April 7, 2022 - 10:10:36 AM
Long-term archiving on: : Wednesday, October 6, 2021 - 6:28:41 PM


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Zania Diabasana, Jeanne-Marie Perotin, Randa Belgacemi, Julien Ancel, Pauline Mulette, et al.. Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia. International Journal of Molecular Sciences, MDPI, 2021, 22 (13), pp.6657. ⟨10.3390/ijms22136657⟩. ⟨hal-03278065⟩



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