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Journal Articles Infection Year : 2022

Relationship between serotypes, disease characteristics and 30-day mortality in adults with invasive pneumococcal disease

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Kostas Danis
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Nathalie Brieu
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Jacques Gaillat
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Bruno Mourvillier
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Pierre-Edouard Bollaert
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  • IdRef : 059868732
Olivier Gaillot
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Muhamed-Kheir Taha
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Stephane Bonacorsi
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Marc Lecuit
Bruno Frachet
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Thomas Debroucker
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Daniel Levy Bruhl
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Marie Preau
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Nadia Anguel
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Laurent Argaud
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Sophie Arista
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Laurence Armand-Lefevre
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Stéphanie Balavoine
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Régine Baraduc
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Guilène Barnaud
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Guillaume Béraud
Georges Bernars
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Dominique Bertei
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Emilie Bessede
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Typhaine Billard Pomares
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Charlotte Biron
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Stéphane Bland
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Julien Boileau
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Patrice Boubeau
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Sandra Bourdon
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Aurore Bousquet
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Sophie Boyer
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Alexis Bozorg-Grayeli
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Cédric Bretonniere
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François Bricaire
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Elsa Brocas
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Michel Brun
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Jennifer Buret
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Christophe Burucoa
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Jean Cabalion
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Mathieu Cabon
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Emmanuelle Cambau
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Guillaume Camuset
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Christophe Canevet
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François Caron
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Anne Carricajo
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Bernard Castan
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Eric Caumes
Charles Cazanave
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Amélie Chabrol
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Thibaut Challan-Belval
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Chantal Chaplain
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Caroline Charlier-Woerther
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Hélène Chaussade
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Bernard Clair
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Julien Colot
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Jean-Marie Conil
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Hugues Cordel
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Philippe Cormier
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Joël Cousson
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Pierrick Cronier
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Eric Cua
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Anne Dao-Dubremetz
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Sylvie Dargere
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Nicolas Degand
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Sophie Dekeyser
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Deborah Delaune
Eric Denes
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Pierre-Francois Dequin
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Diane Descamps
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Elodie Descloux
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Jean-Luc Desmaretz
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Jean-Luc Diehl
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Jérôme Dimet
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Aurélien Dinh
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Lelia Escaut
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Claude Fabe
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Frédéric Faibis
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Clara Flateau
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Nathalie Fonsale
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Nicolas Fortineau
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Amandine Gagneux-Brunon
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Caroline Garandeau
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Magali Garcia
Denis Garot
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Stéphane Gaudry
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François Goehringer
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Alain Gravet
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Valérie Gregoire-Faucher
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Marine Grosset
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Isabelle Gueit
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Dominique Guelon
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Thomas Guimard
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Tahar Hadou
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Jean-Pierre Helene
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Sandrine Henard
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Benoit Henry
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Anne-Cécile Hochart
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Bruno Hoen
Gabriela Illes
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Sylvain Jaffuel
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Irène Jarrin
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Françoise Jaureguy
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Cédric Joseph
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Marie-Emmanuelle Juvin
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Samer Kayal
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Solen Kerneis
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Isabelle Lamaury
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Etienne Laurens
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Henri Laurichesse
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Cécile Le Brun
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Vincent Le Moing
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Paul Le Turnier
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Hervé Lecuyer
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Sylvie Ledru
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Céline Legrix
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Adrien Lemaignen
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Chantal Lemble
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Ludovic Lemee
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Olivier Lesens
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Claire Lhommet
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Silvija Males
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Edith Malpote
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Guillaume Martin-Blondel
Matthieu Marx
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Raphael Masson
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Olivier Matray
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Aurore Mbadi
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Frédéric Mechai
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Guillaume Mellon
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Audrey Merens
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Marie Caroline Meyohas
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Adrien Michon
Joy Mootien Yoganaden
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David Morquin
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Stéphane Mouly
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Natacha Mrozek
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Sophie Nguyen
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Eric Oziol
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Bernard Page
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Solène Patrat-Delon
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Isabelle Patry
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Sandrine Picot
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Denys Pierrejean
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Lionel Piroth
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Claire Plassart
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Patrice Plessis
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Laurent Portel
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Patrice Poubeau
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Marie Poupard
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Claire Poyart
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Thierry Prazuck
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Luc Quaesaet
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François Raffi
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Adriatsiferana Ramanantsoa
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Christophe Rapp
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Laurent Raskine
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Josette Raymond
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Agnès Riche
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Stéphanie Robaday-Voisin
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Frédéric Robin
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Jean-Pierre Romaszko
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Florence Rousseau
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Anne-Laure Roux
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Cécile Royer
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Matthieu Saada
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Dominique Salmon
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Carlo Saroufim
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Jean Luc Schmit
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Manuela Sebire
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Christine Segonds
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Valérie Sivadon-Tardy
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Nathalie Soismier
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Olivia Son
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Simon Sunder
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Florence Suy
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Didier Tande
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Jacques Tankovic
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Nadia Valin
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Nicolas van Grunderbeeck
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François Vandenesch
Emmanuelle Varon
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Renaud Verdon
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Michel Vergnaud
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Magali Vidal
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Daniel Vittecoq
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Fanny Vuotto
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Isabelle Gorenne
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Cédric Laouenan
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Estelle Marcault
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France Mentre
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Blandine Pasquet
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Carine Roy
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Philippe Arsac
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Martha Benoit
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Louis Bernard
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François Bissuel
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Laurent Bret
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Natalie Brieu
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Jennifer Burret
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Claudia Carvalhoschneider
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Hélène Champagne
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Joséphine Chapalain
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Hubert Chardon
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Pascal Chavanet
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Judith Ducruet
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Olivier Epaulard
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Marc Fabre
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Dominique Fasquelle
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Emmanuel Forestier
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Jean-Marc Galempoix
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Guillaume Gautier
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Claire Goulard de Curraize
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Alain Gracet
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Camélia Gubavu
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Jérôme Guinard
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Tarik Habet
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Aurélie Haudour
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Caroline Henry
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Cécile Hombrouckalet
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Céline Janssen
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Jean-Paul Kisteman
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Philippe Lanotte
Marie-Frédérique Lartigue
Claire Launois
Cécile Lebrun
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Laurence Legout
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Marion Levast
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Yannick Madoux
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Laurence Maulin
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Stéphanie Mestrallet
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Abdo Mohareb
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Joy Mootien
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Yohan Nguyen
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Franck Noel
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Maja Ogielska
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Agathe Ogier Desserrey
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Anne Paleau
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Simona Pavel
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André Pechinot
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Isabelle Pelloux
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Camille Petillon
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Hélène Petitprez
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Bianca Podac
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Jerome Poirot
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Bénédicte Ponceau
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Nathalie Prieur
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Christine Recule
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Orlando Saraceni
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Jacques Sartre
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Farid Sifaoui
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Catherine Simonin
Christophe Strady
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Charlotte Tellini
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Anthony Texier
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Maxime Thouvenin
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Anne Tixier
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Pauline Tremeaux
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Pascale Verger
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Jean-Pierre Verquin
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Virginie Vitrat
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Isabelle Vray
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Oana Zamfir
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Laure Zucchini
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Abstract

Purpose: Invasive pneumococcal disease (IPD) is responsible for substantial mortality and morbidity worldwide. We aimed to identify host and bacterial factors associated with 30-day mortality in 18-year-old patients hospitalized with IPD in France from 2013 to 2015. Methods: This study analyzed data collected from consecutives IPD cases included in two parallel multi-center cohort studies: COMBAT study (280 patients with pneumococcal community-acquired bacterial meningitis) and SIIP study (491 patients with non-meningitis IPD). Factors associated with 30-day mortality were identified using logistic regression. Results: Among the 771 enrolled patients (median age 66 years, IQR [52.0-79.7]), 592/767 (77.2%) had at least one chronic disease. Patients with meningitis were younger (60.2 vs 70.9 years; p < 0.001) and had fewer chronic diseases than those with non-meningitis IPD (73.3% vs 79.4%; p = 0.05). Non-vaccine serotypes were more frequent in meningitis patients than in those with other IPD (36.1% vs 23.1%; p < 0.001). The overall 30-day mortality was 16.7% and patients with concurrent meningitis and extra-cerebral IPD had the highest 30-day mortality rate (26.5%). On multivariate analyses, older age, history of malignant solid tumor, meningeal IPD and serotypes previously identified with high mortality potential were independently associated with 30-day mortality. Of the serotypes with high mortality potential, 80% were included in licensed (PCV13 or PPV23) vaccines. Conclusion: We observed an effect of both host factors and pneumococcal serotypes on 30-day mortality in IPD. This highlights the need for a focused strategy to vaccinate at-risk patients. Clinical trial: ClinicalTrial. Gov identification number: NCT01730690.
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Dates and versions

hal-03337583 , version 1 (08-09-2021)

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Amine Benadji, Kostas Danis, Nathalie Brieu, Jacques Gaillat, Bruno Mourvillier, et al.. Relationship between serotypes, disease characteristics and 30-day mortality in adults with invasive pneumococcal disease. Infection, 2022, 50, pp.223-233. ⟨10.1007/s15010-021-01688-5⟩. ⟨hal-03337583⟩
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