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Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study

Abstract : Sialidases, also called neuraminidases, are involved in several human pathologies such as neurodegenerative disorders, cancers, as well as infectious and cardiovascular diseases. Several studies have shown that neuraminidases, such as neuraminidase 1 (NEU-1), may be promising pharmacological targets. Therefore, the discovery of new selective inhibitors of NEU-1 are necessary to better understand the biological functions of this sialidase. In the present study, we describe the isolation and characterization of nine known compounds from Olyra latifolia L. leaves. This plant, known to have several therapeutic properties, belongs to the family of Poaceae and is found in the neotropics and in tropical Africa and Madagascar. Among the purified compounds, feddeiketone B, 2,3-dihydroxy-1-(4-hydroxy-3,5-diméthoxyphényl)-l-propanone, and syringylglycerol were shown to present structural analogy with DANA, and their effects on membrane NEU-1 sialidase activity were evaluated. Our results show that they possess inhibitory effects against NEU-1-mediated sialidase activity at the plasma membrane. In conclusion, we identified new natural bioactive molecules extracted from Olyra latifolia as inhibitors of human NEU-1 of strong interest to elucidate the biological functions of this sialidase and to target this protein involved in several pathophysiological contexts.
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https://hal.univ-reims.fr/hal-03339958
Contributor : Laurence Voutquenne Connect in order to contact the contributor
Submitted on : Thursday, September 9, 2021 - 6:26:02 PM
Last modification on : Friday, February 25, 2022 - 2:18:39 PM
Long-term archiving on: : Saturday, December 11, 2021 - 7:26:29 AM

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Camille Albrecht, Zachée Louis Evariste Akissi, Philomène Akoua Yao-Kouassi, Abdulmagid Alabdul Magid, Pascal Maurice, et al.. Identification and Evaluation of New Potential Inhibitors of Human Neuraminidase 1 Extracted from Olyra latifolia L.: A Preliminary Study. Biomedicines, MDPI, 2021, 9 (4), pp.411. ⟨10.3390/biomedicines9040411⟩. ⟨hal-03339958⟩

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