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Two new bis-iridoids isolated from Scabiosa stellata and their antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities

Abstract : This study presents the chemical profile investigation of a 70% ethanol extract obtained from Scabiosa stellata, a medicinal herbaceous traditionally used to treat heel cracks. A 13C NMR-based dereplication methodology was firstly applied on centrifugal partition chromatography-generated fractions in order to quickly identify the major compounds of the extract. The dereplication process was then completed by semi-preparative high-performance liquid chromatography in order to identify unknown or minor compounds. Two new bis-iridoids, namely 7-O-caffeoyl-sylvestroside I (1) and 7-O-(p-coumaroyl)-sylvestroside I (2), together with ten known compounds (3 − 12) were isolated. Their structures were elucidated by spectroscopic methods including NMR and HR-ESI-MS. The antibacterial, anti-tyrosinase and DPPH radical scavenging activities of the crude extract, fractions, and isolated compounds were evaluated. A significant antibacterial activity was observed for nine isolated compounds, particularly 1 and 2 which yielded MIC values of 31.2 μg/mL against Enterococcus faecalis and 62.5 μg/mL against Staphylococcus epidermidis. The cytotoxic activity of these new bis-iridoids was evaluated on a fibrosarcoma cell line (HT1080) and only compound 1 exhibited a moderate cytotoxic activity (IC50 35.9 μg/mL).
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https://hal.univ-reims.fr/hal-03351296
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Submitted on : Wednesday, September 22, 2021 - 12:13:30 PM
Last modification on : Wednesday, February 23, 2022 - 9:14:03 AM
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Meryem Lehbili, Abdulmagid Alabdul Magid, Jane Hubert, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, et al.. Two new bis-iridoids isolated from Scabiosa stellata and their antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities. Fitoterapia, Elsevier, 2018, 125, pp.41 - 48. ⟨10.1016/j.fitote.2017.12.018⟩. ⟨hal-03351296⟩

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