Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria

Eight undescribed triterpenoid saponins, scabiostellatosides A-H, together with three known compounds were isolated from the whole plant of Scabiosa stellata L. Their structures were established by spectroscopic analyses (1D, 2D-NMR and HRESIMS) and chemical methods. Scabiostellatosides A-H were evaluated for their cytotoxicity against human fibrosarcoma cell line (HT1080). Scabiostellatoside F, a heptasaccharide derivative of oleanolic acid, exhibited moderate cytotoxicity against HT1080 cell line with IC50 value of 12.0 μM.

Mots clés

Scabiosa stellate Cav. Caprifoliaceae triterpenoid saponins cytotoxic activity

Domaines

Chimie thérapeutique Chimie analytique Botanique

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Manuscrit Scabiosa stellataR1_HAL.pdf (1.05 Mo)

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Laurence VOUTQUENNE : Connectez-vous pour contacter le contributeur

https://hal.univ-reims.fr/hal-03351420

Soumis le : mercredi 22 septembre 2021-12:22:52

Dernière modification le : lundi 22 avril 2024-09:38:04

Archivage à long terme le : jeudi 23 décembre 2021-18:37:07

Dates et versions

hal-03351420 , version 1 (22-09-2021)

Identifiants

HAL Id : hal-03351420 , version 1
DOI : 10.1016/j.phytochem.2018.03.005

Citer

Meryem Lehbili, Abdulmagid Alabdul Magid, Ahmed Kabouche, Laurence Voutquenne-Nazabadioko, Hamid Morjani, et al.. Triterpenoid saponins from Scabiosa stellata collected in North-eastern Algeria. Phytochemistry, 2018, 150, pp.40-49. ⟨10.1016/j.phytochem.2018.03.005⟩. ⟨hal-03351420⟩

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