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F4, a collagen XIX-derived peptide, inhibits tumor angiogenesis through αvβ3 and α5β1 integrin interaction

Abstract : We previously demonstrated that F4 peptide (CNPEDCLYPVSHAHQR) from collagen XIX was able to inhibit melanoma cell migrationin vitro and cancer progression in a mouse melanoma model. The aim of the present work was to study the anti-angiogenic properties of F4 peptide. We demonstrated that F4 peptide inhibited VEGF-induced pseudo-tube formation on Matrigel by endothelial cells and endothelial sprouting in a rat aortic ring assay. By affinity chromatography, we identified αvβ3 and α5β1 integrins as potential receptors for F4 peptide on endothelial cell surface. Using solid phase assays, we proved the direct interaction between F4 and both integrins. Taken together, our results demonstrate that F4 peptide is a potent antitumor agent inhibiting both angiogenesis and tumor cell migration.
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https://hal.univ-reims.fr/hal-03373617
Contributor : Jean-Marc Ferez Connect in order to contact the contributor
Submitted on : Monday, October 11, 2021 - 3:37:55 PM
Last modification on : Thursday, October 14, 2021 - 1:10:09 PM

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Jean-Baptiste Oudart, Matthieu Villemin, Bertrand Brassart, Christèle Sellier, Christine Terryn, et al.. F4, a collagen XIX-derived peptide, inhibits tumor angiogenesis through αvβ3 and α5β1 integrin interaction. Cell Adhesion and Migration, Taylor & Francis, 2021, 15 (1), pp.215-223. ⟨10.1080/19336918.2021.1951425⟩. ⟨hal-03373617⟩

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