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Corticosteroid therapy for patients with COVID-19 pneumonia: a before–after study

Abstract : Anti-inflammatory drugs such as corticosteroids may beneficially modulate the host inflammatory response to coronavirus disease 2019 (COVID-19) pneumonia. The aim of this study was to evaluate the impact of addition of corticosteroids to the hospital protocol for treatment of suspected or confirmed COVID-19 pneumonia on rates of death or intensive care unit (ICU) admission. A before-after study was performed to evaluate the effect of addition of corticosteroids to our institution's COVID-19 treatment protocol on hospital mortality. A total of 257 patients with a COVID-19 diagnosis were included in this study between 3 March 2020 and 14 April 2020. As corticosteroids were widely used after 27 March 2020, two periods were considered for the purposes of this study: the 'before' period from 3-20 March 2020 (n = 85); and the 'after' period from 26 March-14 April 2020 (n = 172). The 'after' period was associated with a lower risk of death [adjusted hazard ratio (aHR) = 0.47, 95% confidence interval (CI) 0.23-0.97; P = 0.04] and a lower risk of ICU admission or of death before ICU admission (aHR = 0.37, 95% CI 0.21-0.64; P = 0.0 0 05) by multivariate analysis adjusted for age, National Early Warning score and institutionalisation status. In conclusion, addition of corticosteroids to our institution's COVID-19 treatment protocol was associated with a significant reduction in hospital mortality in the 'after' period.
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https://hal.univ-reims.fr/hal-03425066
Contributor : Arnaud Pommier Connect in order to contact the contributor
Submitted on : Friday, November 12, 2021 - 3:00:34 PM
Last modification on : Saturday, November 13, 2021 - 3:18:42 AM

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Firouzé Bani-Sadr, Maxime Hentzien, Madeline Pascard, Yohan N'Guyen, Amélie Servettaz, et al.. Corticosteroid therapy for patients with COVID-19 pneumonia: a before–after study. International Journal of Antimicrobial Agents, 2020, 56, ⟨10.1016/j.ijantimicag.2020.106077⟩. ⟨hal-03425066⟩

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