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Severe Attack of Henoch-Schönlein Purpura With Neurological Involvement During Adalimumab Treatment for Crohn’s Disease

Morgane Condamina 1 Emmanuelle Diaz 1 Céline Jamart 2 Jeffrey Loget 1 Anne Durlach 3 Jean-Hugues Salmon 3 Guillaume Cadiot 1 Manuelle Viguier 4, 1 
1 Hôpital universitaire Robert Debré [Reims]
2 Hôpital Cochin [AP-HP]
3 Hôpital Maison Blanche
4 IRMAIC - Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509
Abstract : Tumour necrosis factor-α [TNF-α] inhibitors have revolutionised the management of chronic inflammatory conditions. A number of cutaneous adverse events have been reported with TNF inhibition, including vasculitis. Most reactions are mild and rarely warrant treatment withdrawal. Here we describe a patient with Crohn's disease treated with adalimumab in whom severe multivisceral Henoch-Schönlein purpura developed, including neurological involvement, requiring definitive TNF blocker withdrawal.
Keywords : Henoch-Schönlein purpura adalimumab Crohn's disease endoscopy pathology Henoch-Schönlein purpura
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https://hal.univ-reims.fr/hal-03434390
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Submitted on : Friday, November 19, 2021 - 3:13:57 PM
Last modification on : Saturday, November 20, 2021 - 3:18:21 AM

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Morgane Condamina, Emmanuelle Diaz, Céline Jamart, Jeffrey Loget, Anne Durlach, et al.. Severe Attack of Henoch-Schönlein Purpura With Neurological Involvement During Adalimumab Treatment for Crohn’s Disease. Journal of Crohn's and Colitis, Elsevier - Oxford University Press, 2019, 14 (4), pp.538 - 542. ⟨10.1093/ecco-jcc/jjz164⟩. ⟨hal-03434390⟩

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