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Large International Validation of ABSIS and PDAI Pemphigus Severity Scores

Vivien Hébert Claire Boulard Estelle Houivet Sophie Lehembre Luca Borradori Rocco Della Claudio Feliciani Luca Fania Giovanna Zambruno Diana Camaioni Biago Didona Branka Marinovic Enno Schmidt Nina Schumacher Christian Hü Nefeld 10 Stefan Schanz Johannes Kern Silke Hofmann Anne Bouyeure Catherine Picard-Dahan Catherine Prost-Squarcioni Frederic Caux Marina Alexandre Saskia Ingen-Housz-Oro Martine Bagot Emmanuelle Tancrede-Bohin Jean David Bouaziz Nathalie Franck Pierre Vabres Bruno Labeille Marie Richard Emmanuel Delaporte Alain Dupuy Michel d'Incan Gaelle Quereux François Skowro Carle Paul Cristina Livideanu Marie Beylot-Barry Marie Doutre Martine Avenel-Audran Christophe Bedane Philippe Bernard 1, 2 Laurent Machet Hervé Maillard Denis Jullien Sebastien Debarbieux Bruno Sassolas Laurent Misery Claire Abasq Olivier Dereure Philippe Lagoutte Vincent Ferranti Victoria Werth Dedee Murrell Michael Hertl Jacques Benichou Pascal Joly Sophie Duvert Lehembre Rocco Della Torre Christian Hünefeld Johannes Steffen Kern Anne Charlotte Bouyeure Jean David Bouaziz Marie Aleth Richard Michel D’incan Cristina Bulai Livideanu Marie Sylvie Doutre
1 CHU Reims - Centre Hospitalier Universitaire de Reims
2 IRMAIC - Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509
Abstract : (ABSIS) scores have been proposed to provide an objective measure of pemphigus activity. These scores have been evaluated only on already treated patients mainly with mild to moderate activity. The objective was to assess the interrater reliability of ABSIS and PDAI scores and their correlation with other severity markers in a large international study. Consecutive patients with newly diagnosed pemphigus were enrolled in 31 centers. Severity scores were recorded during a 24-month period by the same two blinded investigators. Serum was collected at each visit for ELISA measurement of anti-desmoglein antibodies. The intraclass correlation coefficient (ICC) and Spearman rank correlation coefficient were calculated. A total of 116 patients with pemphigus vulgaris (n ¼ 84) or pemphigus foliaceus (n ¼ 32) were
Keywords : ABSIS Autoimmune Bullous Skin Disorder Intensity Score CI confidence interval DLQI Dermatology Quality of Life Index ICC intraclass correlation coefficient M month PDAI Pemphigus Disease Area Index PF pemphigus foliaceus PGA Physician Global Assessment PV pemphigus vulgaris
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https://hal.univ-reims.fr/hal-03436997
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Submitted on : Friday, November 19, 2021 - 4:06:09 PM
Last modification on : Tuesday, December 7, 2021 - 3:16:59 AM
Long-term archiving on: : Sunday, February 20, 2022 - 8:52:49 PM

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Vivien Hébert, Claire Boulard, Estelle Houivet, Sophie Lehembre, Luca Borradori, et al.. Large International Validation of ABSIS and PDAI Pemphigus Severity Scores. Journal of Investigative Dermatology, Nature Publishing Group, 2019, 139 (1), pp.31-37. ⟨10.1016/j.jid.2018.04.042⟩. ⟨hal-03436997⟩

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