Skip to Main content Skip to Navigation
Journal articles

Antibiotic Tolerance of Staphylococcus aureus Biofilm in Periprosthetic Joint Infections and Antibiofilm Strategies

Abstract : The need for bone and joint prostheses is currently growing due to population aging, leading to an increase in prosthetic joint infection cases. Biofilms represent an adaptive and quite common bacterial response to several stress factors which confer an important protection to bacteria. Biofilm formation starts with bacterial adhesion on a surface, such as an orthopedic prosthesis, further reinforced by matrix synthesis. The biofilm formation and structure depend on the immediate environment of the bacteria. In the case of infection, the periprosthetic joint environment represents a particular interface between bacteria, host cells, and the implant, favoring biofilm initiation and maturation. Treating such an infection represents a huge challenge because of the biofilm-specific high tolerance to antibiotics and its ability to evade the immune system. It is crucial to understand these mechanisms in order to find new and adapted strategies to prevent and eradicate implant-associated infections. Therefore, adapted models mimicking the infectious site are of utmost importance to recreate a relevant environment in order to test potential antibiofilm molecules. In periprosthetic joint infections, Staphylococcus aureus is mainly involved because of its high adaptation to the human physiology. The current review deals with the mechanisms involved in the antibiotic resistance and tolerance of Staphylococcus aureus in the particular periprosthetic joint infection context, and exposes different strategies to manage these infections.
Document type :
Journal articles
Complete list of metadata
Contributor : Marius Colin Connect in order to contact the contributor
Submitted on : Friday, December 3, 2021 - 12:33:26 PM
Last modification on : Friday, August 5, 2022 - 11:24:55 AM
Long-term archiving on: : Friday, March 4, 2022 - 7:00:46 PM


Lamret et al. (2020) - Antibio...
Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License




Fabien Lamret, Marius Colin, Céline Mongaret, Sophie Gangloff, Fany Reffuveille. Antibiotic Tolerance of Staphylococcus aureus Biofilm in Periprosthetic Joint Infections and Antibiofilm Strategies. Antibiotics, MDPI, 2020, 9, ⟨10.3390/antibiotics9090547⟩. ⟨hal-03464585⟩



Record views


Files downloads