Berberine as a Potential Anticancer Agent: A Comprehensive Review - Archive ouverte HAL Access content directly
Journal Articles Molecules Year : 2021

Berberine as a Potential Anticancer Agent: A Comprehensive Review

, , , , , , , , , , , , (1) ,
1
Abdur Rauf
Tareq Abu-Izneid
  • Function : Author
Anees Ahmed Khalil
Muhammad Imran
Zafar Ali Shah
  • Function : Author
Talha Bin Emran
Saikat Mitra
  • Function : Author
Zidan Khan
  • Function : Author
Fahad Alhumaydhi
Abdullah Aljohani
  • Function : Author
Ishaq Khan
  • Function : Author
Md. Mominur Rahman
Tanweer Aslam Gondal

Abstract

Berberine (BBR), a potential bioactive agent, has remarkable health benefits. A substantial amount of research has been conducted to date to establish the anticancer potential of BBR. The present review consolidates salient information concerning the promising anticancer activity of this compound. The therapeutic efficacy of BBR has been reported in several studies regarding colon, breast, pancreatic, liver, oral, bone, cutaneous, prostate, intestine, and thyroid cancers. BBR prevents cancer cell proliferation by inducing apoptosis and controlling the cell cycle as well as autophagy. BBR also hinders tumor cell invasion and metastasis by down-regulating metastasis-related proteins. Moreover, BBR is also beneficial in the early stages of cancer development by lowering epithelial–mesenchymal transition protein expression. Despite its significance as a potentially promising drug candidate, there are currently no pure berberine preparations approved to treat specific ailments. Hence, this review highlights our current comprehensive knowledge of sources, extraction methods, pharmacokinetic, and pharmacodynamic profiles of berberine, as well as the proposed mechanisms of action associated with its anticancer potential. The information presented here will help provide a baseline for researchers, scientists, and drug developers regarding the use of berberine as a promising candidate in treating different types of cancers.

Dates and versions

hal-03467231 , version 1 (06-12-2021)

Identifiers

Cite

Abdur Rauf, Tareq Abu-Izneid, Anees Ahmed Khalil, Muhammad Imran, Zafar Ali Shah, et al.. Berberine as a Potential Anticancer Agent: A Comprehensive Review. Molecules, 2021, 26 (23), pp.7368. ⟨10.3390/molecules26237368⟩. ⟨hal-03467231⟩

Collections

CNRS URCA RIBP
9 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More