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ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer

Abstract : Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro , we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo , we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression.
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Contributor : Valerian Dormoy Connect in order to contact the contributor
Submitted on : Wednesday, December 8, 2021 - 10:16:57 AM
Last modification on : Friday, February 25, 2022 - 2:44:21 PM
Long-term archiving on: : Wednesday, March 9, 2022 - 6:17:49 PM


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Déborah Neyrinck-Leglantier, Julien Lesage, Silvia Blacher, Arnaud Bonnomet, Walter Hunziker, et al.. ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer. Frontiers in Cell and Developmental Biology, Frontiers media, 2021, 9, pp.749364. ⟨10.3389/fcell.2021.749364⟩. ⟨hal-03470162⟩



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