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Journal Articles Frontiers in Cell and Developmental Biology Year : 2021

ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer

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Abstract

Delocalization of zonula occludens-1 (ZO-1) from tight junctions plays a substantial role in epithelial cell plasticity observed during tumor progression. In vitro , we reported an impact of ZO-1 cyto-nuclear content in modulating the secretion of several pro-inflammatory chemokines. In vivo , we demonstrated that it promotes the recruitment of immune cells in mouse ear sponge assays. Examining lung cancers, we showed that a high density of CD8 cytotoxic T cells and Foxp3 immunosuppressive regulatory T cells in the tumor microenvironment correlated with a cyto-nuclear expression of ZO-1. Taken together, our results support that, by affecting tumor cell secretome, the cyto-nuclear ZO-1 pool may recruit immune cells, which could be permissive for tumor progression.
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Dates and versions

hal-03470162 , version 1 (08-12-2021)

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Déborah Neyrinck-Leglantier, Julien Lesage, Silvia Blacher, Arnaud Bonnomet, Walter Hunziker, et al.. ZO-1 Intracellular Localization Organizes Immune Response in Non-Small Cell Lung Cancer. Frontiers in Cell and Developmental Biology, 2021, 9, pp.749364. ⟨10.3389/fcell.2021.749364⟩. ⟨hal-03470162⟩

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