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Journal articles
Antibacterial and Immunomodulatory Properties of Acellular Wharton’s Jelly Matrix
Abstract : Of all biologic matrices, decellularized tissues have emerged as a promising tool in the field of regenerative medicine. Few empirical clinical studies have shown thatWharton’s jelly (WJ) of the human umbilical cord promotes wound closure and reduces wound-related infections. In this scope, we herein investigated whether decellularized (DC)-WJ could be used as an engineered biomaterial. In comparison with devitalized (DV)-WJ, our results showed an inherent effect of DC-WJ on Gram positive (S. aureus and S. epidermidis) and Gram negative (E. coli and P. aeruginosa) growth and adhesion. Although DC-WJ activated the neutrophils and monocytes in a comparable magnitude to DV-WJ, macrophages modulated their phenotypes and polarization states from the restingM0 phenotype to the hybridM1/M2 phenotype in the presence of DC-WJ.M1 phenotype was predominant in the presence of DV-WJ. Finally, the subcutaneous implantation of DC-WJ showed total resorption after three weeks of implantation without any sign of foreign body reaction. These significant data shed light on the potential regenerative application of DC-WJ in providing a suitable biomaterial for tissue regenerative medicine and an ideal strategy to prevent wound-associated infections.
https://hal.univ-reims.fr/hal-03545613
Contributor : Marius Colin Connect in order to contact the contributor
Submitted on : Thursday, January 27, 2022 - 12:54:27 PM
Last modification on : Friday, April 8, 2022 - 9:59:07 AM
Contributor : Marius Colin Connect in order to contact the contributor
Submitted on : Thursday, January 27, 2022 - 12:54:27 PM
Last modification on : Friday, April 8, 2022 - 9:59:07 AM
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Dubus et al. (2022) - Antibact...
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