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Journal Articles FEBS Letters Year : 2014

Lumican: A new inhibitor of matrix metalloproteinase-14 activity

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Abstract

We previously showed that lumican regulates MMP-14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP-14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP-14 activity in B16F1 melanoma cells. Our results suggest that a direct interaction occurs between lumican and MMP-14. Lumican behaves as a competitive inhibitor which leads to a complete blocking of the activity of MMP-14. It binds to the catalytic domain of MMP-14 with moderate affinity (K D ∼ 275 nM). Lumican may protect collagen against MMP-14 proteolysis, thus influencing cell–matrix interaction in tumor progression.

Dates and versions

hal-03557802 , version 1 (04-02-2022)

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Katarzyna Pietraszek, Aurore Chatron-Colliet, Stéphane Brézillon, Corinne Perreau, Anna Jakubiak-Augustyn, et al.. Lumican: A new inhibitor of matrix metalloproteinase-14 activity. FEBS Letters, 2014, 588 (23), pp.4319-4324. ⟨10.1016/j.febslet.2014.09.040⟩. ⟨hal-03557802⟩

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