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Lumican: A new inhibitor of matrix metalloproteinase-14 activity

Abstract : We previously showed that lumican regulates MMP-14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP-14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP-14 activity in B16F1 melanoma cells. Our results suggest that a direct interaction occurs between lumican and MMP-14. Lumican behaves as a competitive inhibitor which leads to a complete blocking of the activity of MMP-14. It binds to the catalytic domain of MMP-14 with moderate affinity (K D ∼ 275 nM). Lumican may protect collagen against MMP-14 proteolysis, thus influencing cell–matrix interaction in tumor progression.
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https://hal.univ-reims.fr/hal-03557802
Contributor : Jean-Marc Ferez Connect in order to contact the contributor
Submitted on : Friday, February 4, 2022 - 3:30:19 PM
Last modification on : Friday, February 25, 2022 - 11:18:03 AM

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Katarzyna Pietraszek, Aurore Chatron-Colliet, Stéphane Brézillon, Corinne Perreau, Anna Jakubiak-Augustyn, et al.. Lumican: A new inhibitor of matrix metalloproteinase-14 activity. FEBS Letters, Wiley, 2014, 588 (23), pp.4319-4324. ⟨10.1016/j.febslet.2014.09.040⟩. ⟨hal-03557802⟩

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