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Journal articles
Management of dental extraction in patients undergoing anticoagulant oral direct treatment: a pilot study
Abstract : Objective. The main goal of this study was to compare the incidence of postoperative bleeding events after dental extractions
between patients treated with direct oral anticoagulants (DOACs) and those treated with vitamin K antagonists (VKAs) without
withdrawal of oral anticoagulant therapy (OAT). Our second objective was to evaluate the risk factors affecting postoperative
hemorrhage after tooth extraction in patients taking DOACs.
Study Design. This prospective observational study included 51 patients who were being treated with oral anticoagulants and
required dental extractions. They were divided into two groups: 31 patients receiving a DOAC and 20 control patients taking
VKA with an international normalized ratio between 2.0 and 3.0. In both groups, extractions were performed under continued
OAT, and the same local hemostatic measures were applied. All procedures were performed in an outpatient facility. A
bleeding event was defined as persistent oozing or marked hemorrhage over 20 minutes after tooth extraction despite local
hemostasis procedures or all bleeding episode occurring during the first postoperative week.
Results. Five patients taking DOACs had seven bleeding episodes, and four patients receiving VKAs had five bleeding
episodes during the postoperative follow-up period. The difference in the number of bleeding events between the two groups
was not statistically significant (adjusted odds ratio ¼ 0.77; 95% confidence interval 0.19-3.19; P ¼ .723). Eleven (91.67%)
bleeding events were mild and controlled by mechanical compression with gauzes, and one (8.33 %) was managed with a
revision of the wound, application of fibrin glue, and resuturing. No bleeding required hospitalization or blood transfusion. All
bleeding episodes occurred during the first 3 postoperative days.
Conclusions. According to our preliminary outcome data, dental extractions can be performed safely in an outpatient facility
in patients treated with DOAC by applying local hemostatic measures, without interrupting or modifying OAT. (Oral Surg Oral
Med Oral Pathol Oral Radiol 2016;122:e146-e155)
https://hal.univ-reims.fr/hal-03579073
Contributor : Marius Colin Connect in order to contact the contributor
Submitted on : Thursday, February 17, 2022 - 5:51:34 PM
Last modification on : Friday, February 25, 2022 - 11:35:21 AM
Contributor : Marius Colin Connect in order to contact the contributor
Submitted on : Thursday, February 17, 2022 - 5:51:34 PM
Last modification on : Friday, February 25, 2022 - 11:35:21 AM