Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
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Kaj Blennow
- Function : Author
- PersonId : 763020
- ORCID : 0000-0002-1890-4193
Daniel Alcolea
- Function : Author
- PersonId : 797376
- ORCID : 0000-0002-3819-3245
Miles Chapman
- Function : Author
Julien Dumurgier
- Function : Author
- PersonId : 764398
- ORCID : 0000-0003-2070-9706
Diane Dufour-Rainfray
- Function : Author
- PersonId : 918233
Audrey Gabelle
- Function : Author
- PersonId : 757644
- ORCID : 0000-0002-7648-9194
Elisabetta Galloni
- Function : Author
Melanie Hart
- Function : Author
Andreas Jeromin
- Function : Author
Ashvini Keshavan
- Function : Author
Alberto Lleó
- Function : Author
- PersonId : 792181
- ORCID : 0000-0002-2568-5478
Markus Otto
- Function : Author
- PersonId : 761030
- ORCID : 0000-0002-6647-5944
Benoit Rucheton
- Function : Author
- PersonId : 775045
- ORCID : 0000-0002-5893-6595
Jonathan Schott
- Function : Author
Hayrettin Tumani
- Function : Author
- PersonId : 763716
- ORCID : 0000-0002-1647-6201
Federico Verde
- Function : Author
Sylvain Lehmann
- Function : Author
- PersonId : 757920
- ORCID : 0000-0001-6117-562X
- IdRef : 079263305
Abstract
Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests.
Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients.
Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis.
Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.
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Alzheimer s Dementia - 2021 - Delaby - Clinical reporting following the quantification of cerebrospinal fluid biomarkers.pdf (252.13 Ko)
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Origin : Publication funded by an institution
