Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
Constance Delaby
(1, 2, 3, 4)
,
Charlotte Teunissen
(5, 6)
,
Kaj Blennow
(7)
,
Daniel Alcolea
(2, 3)
,
Ivan Arisi
(8)
,
Elodie Bouaziz Amar
(9)
,
Anne Beaume
(10)
,
Aurélie Bedel
(11)
,
Giovanni Bellomo
(12)
,
Edith Bigot‐corbel
(13)
,
Maria Bjerke
(14, 15)
,
Marie‐céline Blanc‐quintin
(16)
,
Mercè Boada
(17, 18)
,
Olivier Bousiges
(19, 20, 21)
,
Miles Chapman
,
Mari Demarco
(22)
,
Mara d'Onofrio
(8)
,
Julien Dumurgier
(9)
,
Diane Dufour-Rainfray
(23, 24)
,
Sebastiaan Engelborghs
(14, 15)
,
Hermann Esselmann
(25)
,
Anne Fogli
(26)
,
Audrey Gabelle
(1)
,
Elisabetta Galloni
,
Clémentine Gondolf
(27)
,
Frédérique Grandhomme
(27)
,
Oriol Grau‐rivera
(28)
,
Melanie Hart
,
Takeshi Ikeuchi
(29)
,
Andreas Jeromin
,
Kensaku Kasuga
(29)
,
Ashvini Keshavan
,
Michael Khalil
(30)
,
Peter Körtvelyessy
(31, 32, 33, 34)
,
Agnieszka Kulczynska‐przybik
(35)
,
Jean‐louis Laplanche
(9)
,
Piotr Lewczuk
(35, 36, 37)
,
Qiao‐xin Li
(38)
,
Alberto Lleó
(3, 2)
,
Catherine Malaplate
(39)
,
Marta Marquié
(17, 18)
,
Colin Masters
(38)
,
Barbara Mroczko
(35)
,
Léonor Nogueira
(40)
,
Adelina Orellana
(17, 18)
,
Markus Otto
(41)
,
Jean‐baptiste Oudart
(42)
,
Claire Paquet
(9)
,
Federico Paolini Paoletti
(12)
,
Lucilla Parnetti
(12)
,
Armand Perret‐liaudet
(43, 44)
,
Katell Peoc'H
(45)
,
Koen Poesen
(46)
,
Albert Puig‐pijoan
(28)
,
Isabelle Quadrio
(43, 44)
,
Muriel Quillard‐muraine
(47)
,
Benoit Rucheton
(48, 49)
,
Susanna Schraen
(50, 51)
,
Jonathan Schott
,
Leslie Shaw
(52)
,
Marc Suárez‐calvet
(28)
,
Magda Tsolaki
(53)
,
Hayrettin Tumani
,
Chinedu Udeh‐momoh
(54)
,
Lucie Vaudran
(55, 56)
,
Marcel Verbeek
(57)
,
Federico Verde
,
Lisa Vermunt
(5, 6)
,
Jonathan Vogelgsang
(25, 58, 59)
,
Jens Wiltfang
(25, 34, 60)
,
Henrik Zetterberg
(7, 61, 62, 63)
,
Sylvain Lehmann
(1, 4)
1
CHRU Montpellier -
Centre Hospitalier Régional Universitaire [Montpellier]
2 UAB - Universitat Autònoma de Barcelona
3 Hospital de la Santa Creu i Sant Pau
4 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
5 Amsterdam UMC - Amsterdam University Medical Center
6 VU - Vrije Universiteit Amsterdam [Amsterdam]
7 Sahlgrenska Academy at University of Gothenburg [Göteborg]
8 EBRI - European Brain Research Institute [Rome, Italy]
9 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
10 CHU Poitiers - Centre hospitalier universitaire de Poitiers
11 CHU Bordeaux [Bordeaux]
12 UNIPG - Università degli Studi di Perugia = University of Perugia
13 CHU Nantes - Centre hospitalier universitaire de Nantes
14 VUB - Vrije Universiteit Brussel
15 UA - University of Antwerp
16 Hôpital Cochin [AP-HP]
17 UIC - Universitat Internacional de Catalunya [Barcelona]
18 CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas
19 Laboratoire de Biochimie et de Biologie Moléculaire
20 ICube - Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie
21 FMTS - Fédération de Médecine Translationnelle de Strasbourg
22 UBC - University of British Columbia
23 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
24 iBrain - Inserm U1253 - UNIV Tours - Imagerie et cerveau
25 UMG - University Medical Center Göttingen
26 CHU Clermont-Ferrand
27 CHU Caen
28 IMIM-Hospital del Mar
29 Niigata University
30 Medical University of Graz
31 Freie Universität Berlin
32 Humboldt University Of Berlin
33 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
34 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
35 MUB - Medical University of Białystok
36 Universitätsklinikum Erlangen [Erlangen]
37 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg
38 The Florey Institute of Neuroscience and Mental Health
39 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
40 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
41 Universität Ulm - Ulm University [Ulm, Allemagne]
42 MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369
43 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
44 HCL - Hospices Civils de Lyon
45 Hôpital Beaujon [AP-HP]
46 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
47 CHU Rouen
48 DMU BioGem - Département Médico-Universitaire Biologie et Génomique Médicales [Sorbonne Université]
49 SU - Sorbonne Université
50 LilNCog - Lille Neurosciences & Cognition - U 1172
51 Excellence Laboratory LabEx DISTALZ
52 University of Pennsylvania
53 Aristotle University of Thessaloniki
54 Imperial College London
55 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
56 Université de Lille
57 Radboud University Medical Center [Nijmegen]
58 McLean Hospital [Belmont, Ma.]
59 HMS - Harvard Medical School [Boston]
60 Universidade de Aveiro
61 Sahlgrenska University Hospital [Gothenburg]
62 UK DRI - UK Dementia Research Institute
63 Institute of Neurology [London]
2 UAB - Universitat Autònoma de Barcelona
3 Hospital de la Santa Creu i Sant Pau
4 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
5 Amsterdam UMC - Amsterdam University Medical Center
6 VU - Vrije Universiteit Amsterdam [Amsterdam]
7 Sahlgrenska Academy at University of Gothenburg [Göteborg]
8 EBRI - European Brain Research Institute [Rome, Italy]
9 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
10 CHU Poitiers - Centre hospitalier universitaire de Poitiers
11 CHU Bordeaux [Bordeaux]
12 UNIPG - Università degli Studi di Perugia = University of Perugia
13 CHU Nantes - Centre hospitalier universitaire de Nantes
14 VUB - Vrije Universiteit Brussel
15 UA - University of Antwerp
16 Hôpital Cochin [AP-HP]
17 UIC - Universitat Internacional de Catalunya [Barcelona]
18 CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas
19 Laboratoire de Biochimie et de Biologie Moléculaire
20 ICube - Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie
21 FMTS - Fédération de Médecine Translationnelle de Strasbourg
22 UBC - University of British Columbia
23 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
24 iBrain - Inserm U1253 - UNIV Tours - Imagerie et cerveau
25 UMG - University Medical Center Göttingen
26 CHU Clermont-Ferrand
27 CHU Caen
28 IMIM-Hospital del Mar
29 Niigata University
30 Medical University of Graz
31 Freie Universität Berlin
32 Humboldt University Of Berlin
33 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
34 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
35 MUB - Medical University of Białystok
36 Universitätsklinikum Erlangen [Erlangen]
37 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg
38 The Florey Institute of Neuroscience and Mental Health
39 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
40 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
41 Universität Ulm - Ulm University [Ulm, Allemagne]
42 MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369
43 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
44 HCL - Hospices Civils de Lyon
45 Hôpital Beaujon [AP-HP]
46 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven
47 CHU Rouen
48 DMU BioGem - Département Médico-Universitaire Biologie et Génomique Médicales [Sorbonne Université]
49 SU - Sorbonne Université
50 LilNCog - Lille Neurosciences & Cognition - U 1172
51 Excellence Laboratory LabEx DISTALZ
52 University of Pennsylvania
53 Aristotle University of Thessaloniki
54 Imperial College London
55 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]
56 Université de Lille
57 Radboud University Medical Center [Nijmegen]
58 McLean Hospital [Belmont, Ma.]
59 HMS - Harvard Medical School [Boston]
60 Universidade de Aveiro
61 Sahlgrenska University Hospital [Gothenburg]
62 UK DRI - UK Dementia Research Institute
63 Institute of Neurology [London]
Kaj Blennow
- Function : Author
- PersonId : 763020
- ORCID : 0000-0002-1890-4193
Daniel Alcolea
- Function : Author
- PersonId : 797376
- ORCID : 0000-0002-3819-3245
Miles Chapman
- Function : Author
Julien Dumurgier
- Function : Author
- PersonId : 764398
- ORCID : 0000-0003-2070-9706
Diane Dufour-Rainfray
- Function : Author
- PersonId : 918233
Audrey Gabelle
- Function : Author
- PersonId : 757644
- ORCID : 0000-0002-7648-9194
Elisabetta Galloni
- Function : Author
Melanie Hart
- Function : Author
Andreas Jeromin
- Function : Author
Ashvini Keshavan
- Function : Author
Alberto Lleó
- Function : Author
- PersonId : 792181
- ORCID : 0000-0002-2568-5478
Markus Otto
- Function : Author
- PersonId : 761030
- ORCID : 0000-0002-6647-5944
Benoit Rucheton
- Function : Author
- PersonId : 775045
- ORCID : 0000-0002-5893-6595
Jonathan Schott
- Function : Author
Hayrettin Tumani
- Function : Author
- PersonId : 763716
- ORCID : 0000-0002-1647-6201
Federico Verde
- Function : Author
Sylvain Lehmann
- Function : Author
- PersonId : 757920
- ORCID : 0000-0001-6117-562X
- IdRef : 079263305
Abstract
Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests.
Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients.
Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis.
Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.
Fichier principal
Alzheimer s Dementia - 2021 - Delaby - Clinical reporting following the quantification of cerebrospinal fluid biomarkers.pdf (252.13 Ko)
Télécharger le fichier
Origin : Publication funded by an institution
