Journal articles

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Constance Delaby ^{1, 2, 3, 4} Charlotte Teunissen ^{5, 6} Kaj Blennow ⁷ Daniel Alcolea ^{3, 4} Ivan Arisi ⁸ Elodie Bouaziz Amar ⁹ Anne Beaume ¹⁰ Aurélie Bedel ¹¹ Giovanni Bellomo ¹² Edith Bigot‐corbel ¹³ Maria Bjerke ^{14, 15} Marie‐céline Blanc‐quintin ¹⁶ Mercè Boada ^{17, 18} Olivier Bousiges ^{19, 20, 21} Miles Chapman Mari Demarco ²² Mara d'Onofrio ⁸ Julien Dumurgier ⁹ Diane Dufour-Rainfray ^{23, 24} Sebastiaan Engelborghs ^{14, 15} Hermann Esselmann ²⁵ Anne Fogli ²⁶ Audrey Gabelle ¹ Elisabetta Galloni Clémentine Gondolf ²⁷ Frédérique Grandhomme ²⁷ Oriol Grau‐rivera ²⁸ Melanie Hart Takeshi Ikeuchi ²⁹ Andreas Jeromin Kensaku Kasuga ²⁹ Ashvini Keshavan Michael Khalil ³⁰ Peter Körtvelyessy ^{31, 32, 33, 34} Agnieszka Kulczynska‐przybik ³⁵ Jean‐louis Laplanche ⁹ Piotr Lewczuk ^{35, 36, 37} Qiao‐xin Li ³⁸ Alberto Lleó ^{4, 3} Catherine Malaplate ³⁹ Marta Marquié ^{17, 18} Colin Masters ³⁸ Barbara Mroczko ³⁵ Léonor Nogueira ⁴⁰ Adelina Orellana ^{17, 18} Markus Otto ⁴¹ Jean‐baptiste Oudart ⁴² Claire Paquet ⁹ Federico Paolini Paoletti ¹² Lucilla Parnetti ¹² Armand Perret‐liaudet ^{43, 44} Katell Peoc'H ⁴⁵ Koen Poesen ⁴⁶ Albert Puig‐pijoan ²⁸ Isabelle Quadrio ^{43, 44} Muriel Quillard‐muraine ⁴⁷ Benoit Rucheton ^{48, 49} Susanna Schraen ^{50, 51} Jonathan Schott Leslie Shaw ⁵² Marc Suárez‐calvet ²⁸ Magda Tsolaki ⁵³ Hayrettin Tumani Chinedu Udeh‐momoh ⁵⁴ Lucie Vaudran ^{55, 56} Marcel Verbeek ⁵⁷ Federico Verde Lisa Vermunt ^{5, 6} Jonathan Vogelgsang ^{25, 58, 59} Jens Wiltfang ^{25, 34, 60} Henrik Zetterberg ^{7, 61, 62, 63} Sylvain Lehmann ^{1, 2}

1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

2 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)

3 UAB - Universitat Autònoma de Barcelona

4 Hospital de la Santa Creu i Sant Pau

5 Amsterdam UMC - Amsterdam University Medical Center

6 VU - Vrije Universiteit Amsterdam [Amsterdam]

7 Sahlgrenska Academy at University of Gothenburg [Göteborg]

8 EBRI - European Brain Research Institute [Rome, Italy]

9 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]

10 CHU Poitiers - Centre hospitalier universitaire de Poitiers

11 CHU Bordeaux [Bordeaux]

12 UNIPG - Università degli Studi di Perugia

13 CHU Nantes - Centre hospitalier universitaire de Nantes

14 VUB - Vrije Universiteit Brussel

15 UA - University of Antwerp

16 Hôpital Cochin [AP-HP]

17 UIC - Universitat Internacional de Catalunya [Barcelona]

18 CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas

19 Laboratoire de Biochimie et de Biologie Moléculaire

20 ICube - Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie

21 FMTS - Fédération de Médecine Translationnelle de Strasbourg

22 UBC - University of British Columbia

23 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours

24 iBrain - Inserm U1253 - UNIV Tours - Imagerie et cerveau

25 UMG - University Medical Center Göttingen

26 CHU Clermont-Ferrand

27 CHU Caen

28 IMIM-Hospital del Mar

29 Niigata University

30 Medical University of Graz

31 Freie Universität Berlin

32 Humboldt-Universität zu Berlin

33 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]

34 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen

35 MUB - Medical University of Białystok

36 Universitätsklinikum Erlangen [Erlangen]

37 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg

38 The Florey Institute of Neuroscience and Mental Health

39 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy

40 CHU Toulouse [Toulouse]

41 Universität Ulm - Ulm University [Ulm, Allemagne]

42 MEDyC - Matrice extracellulaire et dynamique cellulaire - UMR 7369

43 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center

44 HCL - Hospices Civils de Lyon

45 Hôpital Beaujon [AP-HP]

46 KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven

47 CHU Rouen

48 DMU BioGem - Département Médico-Universitaire Biologie et Génomique Médicales [Sorbonne Université]

49 SU - Sorbonne Université

50 LilNCog - Lille Neurosciences & Cognition - U 1172

51 Excellence Laboratory LabEx DISTALZ

52 University of Pennsylvania [Philadelphia]

53 Aristotle University of Thessaloniki

54 Imperial College London

55 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]

56 Université de Lille

57 Radboud University Medical Center [Nijmegen]

58 McLean Hospital [Belmont, Ma.]

59 HMS - Harvard Medical School [Boston]

60 Universidade de Aveiro

61 Sahlgrenska University Hospital [Gothenburg]

62 UK DRI - UK Dementia Research Institute

63 Institute of Neurology [London]

Abstract : Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.

Keywords : Alzheimer’s disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Neurons and Cognition [q-bio.NC] / Neurobiology

Complete list of metadata

https://hal.univ-reims.fr/hal-03599269
Contributor : Jean-Marc FEREZ Connect in order to contact the contributor
Submitted on : Thursday, April 7, 2022 - 11:41:24 AM
Last modification on : Tuesday, September 27, 2022 - 4:12:59 AM
Long-term archiving on: : Friday, July 8, 2022 - 6:42:13 PM

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Alzheimer s Dementia - 2021 - ...

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