Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview - Université de Reims Champagne-Ardenne Access content directly
Journal Articles Alzheimer's & Dementia : the Journal of the Alzheimer's Association Year : 2022

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Constance Delaby (1, 2, 3, 4) , Charlotte Teunissen (5, 6) , Kaj Blennow (7) , Daniel Alcolea (2, 3) , Ivan Arisi (8) , Elodie Bouaziz Amar (9) , Anne Beaume (10) , Aurélie Bedel (11) , Giovanni Bellomo (12) , Edith Bigot‐corbel (13) , Maria Bjerke (14, 15) , Marie‐céline Blanc‐quintin (16) , Mercè Boada (17, 18) , Olivier Bousiges (19, 20, 21) , Miles Chapman , Mari Demarco (22) , Mara d'Onofrio (8) , Julien Dumurgier (9) , Diane Dufour-Rainfray (23, 24) , Sebastiaan Engelborghs (14, 15) , Hermann Esselmann (25) , Anne Fogli (26) , Audrey Gabelle (1) , Elisabetta Galloni , Clémentine Gondolf (27) , Frédérique Grandhomme (27) , Oriol Grau‐rivera (28) , Melanie Hart , Takeshi Ikeuchi (29) , Andreas Jeromin , Kensaku Kasuga (29) , Ashvini Keshavan , Michael Khalil (30) , Peter Körtvelyessy (31, 32, 33, 34) , Agnieszka Kulczynska‐przybik (35) , Jean‐louis Laplanche (9) , Piotr Lewczuk (35, 36, 37) , Qiao‐xin Li (38) , Alberto Lleó (3, 2) , Catherine Malaplate (39) , Marta Marquié (17, 18) , Colin Masters (38) , Barbara Mroczko (35) , Léonor Nogueira (40) , Adelina Orellana (17, 18) , Markus Otto (41) , Jean‐baptiste Oudart (42) , Claire Paquet (9) , Federico Paolini Paoletti (12) , Lucilla Parnetti (12) , Armand Perret‐liaudet (43, 44) , Katell Peoc'H (45) , Koen Poesen (46) , Albert Puig‐pijoan (28) , Isabelle Quadrio (43, 44) , Muriel Quillard‐muraine (47) , Benoit Rucheton (48, 49) , Susanna Schraen (50, 51) , Jonathan Schott , Leslie Shaw (52) , Marc Suárez‐calvet (28) , Magda Tsolaki (53) , Hayrettin Tumani , Chinedu Udeh‐momoh (54) , Lucie Vaudran (55, 56) , Marcel Verbeek (57) , Federico Verde , Lisa Vermunt (5, 6) , Jonathan Vogelgsang (25, 58, 59) , Jens Wiltfang (25, 34, 60) , Henrik Zetterberg (7, 61, 62, 63) , Sylvain Lehmann (1, 4)
1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
3 Hospital de la Santa Creu i Sant Pau
4 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
5 Amsterdam UMC - Amsterdam University Medical Center
6 VU - Vrije Universiteit Amsterdam [Amsterdam]
7 Sahlgrenska Academy at University of Gothenburg [Göteborg]
8 EBRI - European Brain Research Institute [Rome, Italy]
9 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
10 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
11 CHU Bordeaux
12 UNIPG - Università degli Studi di Perugia = University of Perugia
13 CHU Nantes - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
14 VUB - Vrije Universiteit Brussel [Bruxelles]
15 UA - University of Antwerp
16 Hôpital Cochin [AP-HP]
17 UIC - Universitat Internacional de Catalunya [Barcelona]
18 CIBERNED - Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas
19 Laboratoire de Biochimie et de Biologie Moléculaire
20 ICube - Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie
21 FMTS - Fédération de Médecine Translationnelle de Strasbourg
22 UBC - University of British Columbia
23 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
24 iBraiN - Imaging, Brain & Neuropsychiatry
25 UMG - University Medical Center Göttingen
26 CHU Clermont-Ferrand
27 CHU Caen
28 IMIM-Hospital del Mar
29 Niigata University
30 Medical University of Graz
31 Freie Universität Berlin
32 HU Berlin - Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin
33 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
34 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
35 MUB - Medical University of Białystok
36 Universitätsklinikum Erlangen [Erlangen]
37 FAU - Friedrich-Alexander Universität Erlangen-Nürnberg = University of Erlangen-Nuremberg
38 The Florey Institute of Neuroscience and Mental Health
39 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
40 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
41 Universität Ulm - Ulm University [Ulm, Allemagne]
42 MEDyC - Matrice Extracellulaire et Dynamique Cellulaire - UMR CNRS 7369
43 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
44 HCL - Hospices Civils de Lyon
45 Hôpital Beaujon [AP-HP]
46 KU Leuven - Catholic University of Leuven = Katholieke Universiteit Leuven
47 CHU Rouen
48 CHU Pitié-Salpêtrière [AP-HP]
49 SU - Sorbonne Université
50 LilNCog - Lille Neurosciences & Cognition - U 1172
51 Excellence Laboratory LabEx DISTALZ
52 University of Pennsylvania
53 Aristotle University of Thessaloniki
54 Imperial College London
55 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
56 Université de Lille
57 Radboud University Medical Center [Nijmegen]
58 McLean Hospital [Belmont, Ma.]
59 HMS - Harvard Medical School [Boston]
60 Universidade de Aveiro
61 Sahlgrenska University Hospital [Gothenburg]
62 UK DRI - UK Dementia Research Institute
63 Institute of Neurology [London]
Aurélie Bedel
  • Function : Author
Miles Chapman
  • Function : Author
Anne Fogli
  • Function : Author
Elisabetta Galloni
  • Function : Author
Clémentine Gondolf
  • Function : Author
Frédérique Grandhomme
  • Function : Author
Melanie Hart
  • Function : Author
Takeshi Ikeuchi
Andreas Jeromin
  • Function : Author
Ashvini Keshavan
  • Function : Author
Jonathan Schott
  • Function : Author
Hayrettin Tumani
Federico Verde
  • Function : Author

Abstract

Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.
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hal-03599269 , version 1 (07-04-2022)

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Attribution - NonCommercial - NoDerivatives

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Constance Delaby, Charlotte Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, et al.. Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2022, ⟨10.1002/alz.12545⟩. ⟨hal-03599269⟩
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