Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview - Archive ouverte HAL Access content directly
Journal Articles Alzheimer's & Dementia Year : 2022

Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

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Miles Chapman
  • Function : Author
Anne Fogli
  • Function : Author
Elisabetta Galloni
  • Function : Author
Clémentine Gondolf
  • Function : Author
Frédérique Grandhomme
  • Function : Author
Melanie Hart
  • Function : Author
Takeshi Ikeuchi
Andreas Jeromin
  • Function : Author
Ashvini Keshavan
  • Function : Author
Jonathan Schott
  • Function : Author
Hayrettin Tumani
Federico Verde
  • Function : Author

Abstract

Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.
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Origin : Publication funded by an institution

Dates and versions

hal-03599269 , version 1 (07-04-2022)

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Attribution - NonCommercial - NoDerivatives - CC BY 4.0

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Constance Delaby, Charlotte Teunissen, Kaj Blennow, Daniel Alcolea, Ivan Arisi, et al.. Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview. Alzheimer's & Dementia , In press, ⟨10.1002/alz.12545⟩. ⟨hal-03599269⟩
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