High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study

Jean-Luc Prétet; Véronique Dalstein; Antoine Touzé; Agnès Beby-Defaux; Patrick Soussan; Élise Jacquin; Philippe Birembaut; Christine Clavel; Christiane Mougin; Alexandra Rousseau; Jean Lacau Saint Guily; G. Agius; S. Albert; E. Babin; J. Badet; C. Badoual; A. Baglin; K. Blanc-Fournier; E. Cassagneau; C. Debry; D. de Raucourt; M. Diebold; X. Dufour; M. Hourseau; R. Lacave; E. Lechapt Zalcman; M. Lefevre; P. Levillain; O. Malard; O. Mauvais; A. Mechine; J. Merol; H. Mirghani; S. Morinière; S. Périé; C. Rousselot; T. Simon

doi:10.1007/s10238-022-00796-2

Journal Articles Clinical and Experimental Medicine Year : 2023

High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study

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Jean-Luc Prétet

Function : Correspondent author
PersonId : 1014842

Connectez-vous pour contacter l'auteur

Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181)

Véronique Dalstein

Function : Author

Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250

Centre Hospitalier Universitaire de Reims

Antoine Touzé

Function : Author
PersonId : 762686
ORCID : 0000-0002-9856-9945
IdRef : 12461258X

Infectiologie et Santé Publique

Agnès Beby-Defaux

Function : Author

Laboratoire Inflammation, Tissus épithéliaux et Cytokines

Patrick Soussan

Function : Author
PersonId : 1173542
IdHAL : soussan
ORCID : 0000-0003-2706-7371

Centre de Recherche Saint-Antoine

Service de virologie [Hôpital Tenon]

Élise Jacquin

Function : Author

Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181)

Philippe Birembaut

Function : Author

Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250

Centre Hospitalier Universitaire de Reims

Christine Clavel

Function : Author

Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250

Centre Hospitalier Universitaire de Reims

Christiane Mougin

Function : Author

Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181)

Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)

Alexandra Rousseau

Function : Author

Unité de Recherche Clinique de l’Est Parisien [CHU Saint-Antoine]

Jean Lacau Saint Guily

Function : Author

Oto-Rhino-Laryngologie Chirurgie cervico-faciale [CHU Tenon]

Fondation Ophtalmologique Adolphe de Rothschild [Paris]

G. Agius

Function : Author

S. Albert

Function : Author

E. Babin

Function : Author

J. Badet

Function : Author

C. Badoual

Function : Author

A. Baglin

Function : Author

K. Blanc-Fournier

Function : Author

E. Cassagneau

Function : Author

C. Debry

Function : Author

D. de Raucourt

Function : Author

M. Diebold

Function : Author

X. Dufour

Function : Author

M. Hourseau

Function : Author

R. Lacave

Function : Author

E. Lechapt Zalcman

Function : Author

M. Lefevre

Function : Author

P. Levillain

Function : Author

O. Malard

Function : Author

O. Mauvais

Function : Author

A. Mechine

Function : Author

J. Merol

Function : Author

H. Mirghani

Function : Author

S. Morinière

Function : Author

S. Périé

Function : Author

C. Rousselot

Function : Author

T. Simon

Function : Author

Abstract

The incidence of oropharyngeal cancers (OPC) is increasing in the world. Among OPC, those induced by human papillomaviruses have a better prognosis than non-HPV-associated OPC. The objective of this study was to highlight the relevance of HPV16 load, HPV16 DNA integration and HPV16-L1 serology on progression-free survival and overall survival of OPC patients. The PAPILLOPHAR cohort consists of 362 patients with oropharyngeal squamous cell carcinomas prospectively followed up for 5 years after treatment. Tumor biopsies and sera were collected at inclusion to investigate tumor HPV DNA/RNA characteristics and HPV16 L1 serology, respectively. Twenty-seven percent of tumor biopsies were HPV DNA- and RNA-positive and HPV16 represented 93% of HPV-positive cases. Among them, neither HPV16 viral load nor HPV16 DNA integration was associated with overall survival (OS) or progression-free survival (PFS). In contrast, high anti-HPV16 L1 antibody titers were significantly associated with a better OS and PFS. This study reveals that HPV16 load and integration are not relevant prognosis biomarkers in OPC patients. Clinical Relevance: High levels of HPV16 L1 antibodies may be useful to predict OPC patient outcome following treatment. ClinicalTrials.gov Identifier: NCT00918710, May 2017.

Keywords

Biomarker Oropharyngeal cancer Papillomavirus Prognosis Biomarker

Domains

Life Sciences [q-bio] Cancer

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https://hal.univ-reims.fr/hal-03603889

Submitted on : Thursday, March 10, 2022-10:52:39 AM

Last modification on : Tuesday, May 23, 2023-9:16:04 AM

Dates and versions

hal-03603889 , version 1 (10-03-2022)

Identifiers

HAL Id : hal-03603889 , version 1
DOI : 10.1007/s10238-022-00796-2
PUBMED : 35199231
WOS : 000760048900001

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Jean-Luc Prétet, Véronique Dalstein, Antoine Touzé, Agnès Beby-Defaux, Patrick Soussan, et al.. High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study. Clinical and Experimental Medicine, 2023, 23 (1), pp.87-96. ⟨10.1007/s10238-022-00796-2⟩. ⟨hal-03603889⟩

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High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study

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